Intensity of in vitro incorporation of 3H-melatonin in the thyroid gland of rabbits with pineal gland hypofunction
| Autor: | E. M. Chagovets, A. N. Cherevko, L. Yu. Sergienko, L. A. Bondarenko, N. N. Sotnik |
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| Rok vydání: | 2012 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Hormonal activity Thyroid Hormones endocrine system diseases Light biology.animal_breed Thyroid Gland Pineal Gland General Biochemistry Genetics and Molecular Biology Melatonin Pineal gland stomatognathic system Hypothyroidism Internal medicine medicine Animals Receptor biology business.industry Thyroid General Medicine Chinchilla rabbit In vitro Endocrinology medicine.anatomical_structure Rabbits business hormones hormone substitutes and hormone antagonists medicine.drug Endocrine gland |
| Zdroj: | Bulletin of experimental biology and medicine. 150(6) |
| ISSN: | 1573-8221 |
| Popis: | The structure and hormonal activity of the thyroid gland and its capacity to bind (3)H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called "latent hypothyroidism" and more intense binding of (3)H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency. |
| Databáze: | OpenAIRE |
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