Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways
| Autor: | Mantavya N. Patel, Thangamani Kannan, Lalgi Hima, Uday P. Pratap, Shaili Gour, Ramasamy Vasantharekha, Srinivasan ThyagaRajan, Hannah P. Priyanka |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Intracellular Fluid Male 0301 basic medicine Aging medicine.medical_specialty Cell signaling Hydrocortisone medicine.medical_treatment Immunology Lymphocyte proliferation Peripheral blood mononuclear cell Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine Humans Immunology and Allergy Endocrine system Testosterone PI3K/AKT/mTOR pathway Immunity Cellular Estradiol business.industry Middle Aged 030104 developmental biology Endocrinology Cytokine Neurology Female Neurology (clinical) business 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Journal of Neuroimmunology. 345:577290 |
| ISSN: | 0165-5728 |
| Popis: | The aim of this study was to investigate the alterations in the neuroendocrine-immune functions by using human peripheral blood mononuclear cells (hPBMCs) from three age groups (young, middle-aged, and old) of men and women for the analyses of lymphocyte proliferation and cytokine production, expression of cell signaling molecules, nitric oxide (NO) production, and expression of p-tyrosine hydroxylase (TH). Serum was examined for levels of testosterone in men, 17-β-estradiol in women, and cortisol in both sexes. Lymphoproliferation, expression of p-ERK, p-CREB, p-Akt, and p-TH, and levels of serum sex steroid hormones declined with age in men and women. However, TNF-α production and serum cortisol level increased with age in men and women. mTOR expression was higher in older men while it was lower in older women. IFN-γ and IL-6 production and expression of p-TH and p-mTOR were differentially regulated in men and women. These results suggest that intracellular signaling mediators may be involved in the age-related alterations in the neuroendocrine-immune interactions in men and women. |
| Databáze: | OpenAIRE |
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