Endogenous adenosine delays the onset of hypoxic depolarization in the rat hippocampus in vitro via an action at A1 receptors
| Autor: | Kevin S. Lee, Theodore Lowenkopf |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Adenosine Purinergic Antagonists In Vitro Techniques Biology Gerbil Hippocampus Adenosine A1 receptor Theophylline Internal medicine medicine Animals Hypoxia Brain Evoked Potentials Molecular Biology General Neuroscience Receptors Purinergic Antagonist Depolarization Purinergic signalling Adenosine A3 receptor Adenosine receptor Rats Endocrinology Neurology (clinical) Gerbillinae Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 609:313-315 |
| ISSN: | 0006-8993 |
| Popis: | The effect of endogenous adenosine on the delay to hypoxic depolarization (HD) was examined utilizing in vitro slices of gerbil hippocampus. Adenosine receptor antagonists were used to block the actions of adenosine during hypoxia, and the delay to HD was measured in the CA1 region. Both a broad spectrum antagonist (theophylline) and an A1 receptor-specific antagonist (8-cyclopentyl-1,3-dimethylxanthine; CPT) shortened the delay to HD. These findings indicate that endogenous adenosine working through A1 receptors prolongs the delay to HD. This effect may contribute to the neuroprotective influence of adenosine and its analogs. |
| Databáze: | OpenAIRE |
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