Molecular epidemiology and clinical impact of rhinovirus infections in adults during three epidemic seasons in 11 European countries (2007-2010)
| Autor: | Anneloes L. van Rijn, Peter Simmonds, Jutte J.C. de Vries, Erik W. van Zwet, Paul Little, Frank E. J. Coenjaerts, Kalina T. Zlateva, Anton M. van Loon, Theo J M Verheij, Christopher C Butler, Margareta Ieven, Herman Goossens, Eric C. J. Claas |
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| Přispěvatelé: | GRACE Study Grp |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Rhinovirus respiratory Infection medicine.disease_cause Asymptomatic 03 medical and health sciences 0302 clinical medicine Lower respiratory tract infection Internal medicine Epidemiology Medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Epidemics Genotyping Respiratory Tract Infections 0303 health sciences Molecular Epidemiology Picornaviridae Infections 030306 microbiology business.industry Respiratory infection Middle Aged medicine.disease Europe Relative risk Female Human medicine Seasons viral infection medicine.symptom business |
| Zdroj: | Thorax, 75(10), 882-890. BMJ PUBLISHING GROUP Thorax |
| ISSN: | 0040-6376 |
| Popis: | BackgroundDifferences in clinical impact between rhinovirus (RVs) species and types in adults are not well established. The objective of this study was to determine the epidemiology and clinical impact of the different RV species.MethodsWe conducted a prospective study of RVs infections in adults with acute cough/lower respiratory tract infection (LRTI) and asymptomatic controls. Subjects were recruited from 16 primary care networks located in 11 European countries between 2007 and 2010. RV detection and genotyping was performed by means of real time and conventional reverse-transcriptase polymerase chain reaction assays, followed by sequence analysis. Clinical data were obtained from medical records and patient symptom diaries.ResultsRVs were detected in 566 (19%) of 3016 symptomatic adults, 102 (4%) of their 2539 follow-up samples and 67 (4%) of 1677 asymptomatic controls. Genotyping was successful for 538 (95%) symptomatic subjects, 86 (84%) follow-up infections and 62 (93%) controls. RV-A was the prevailing species, associated with an increased risk of LRTI as compared with RV-B (relative risk (RR), 4.5; 95% CI 2.5 to 7.9; pInterpretationIn adults, RV-A is significantly more often detected in cases with acute cough/LRTI than RV-C, while RV-B infection is often found in asymptomatic patients. |
| Databáze: | OpenAIRE |
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