Low expression levels of plasma miR-141 are associated with susceptibility to gastric cancer
| Autor: | Lihong Cui, Jun Zhang, Shasha Hu, Tianxi Wang, Rongna Wei, Jingjing Tian |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Kaplan-Meier analysis medicine.disease_cause WHO staging 03 medical and health sciences 0302 clinical medicine In vivo microRNA medicine Lymph node Oncogene business.industry gastric cancer Cancer Articles Cell cycle medicine.disease multivariate Cox regression Molecular medicine miR-141 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Carcinogenesis business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1074 |
| Popis: | MicroRNAs (miRNAs/miRs) offer great potential as biomarkers for the early detection and prognosis of cancer, and the discovery of miRNAs associated with gastric cancer is required. In the present study, the differences in the plasma expression levels of miR-141 between patients with gastric cancer and healthy controls, and the role of miR-141 in gastric cancer cell oncogenesis were investigated. A follow-up study of 164 patients with gastric cancer who underwent tumor resection was conducted, and comparisons with healthy control subjects were drawn. To investigate the biological functions of miR-141, a series of in vitro and in vivo assays were conducted, including proliferation, wound-healing and Transwell assays, and a xenograft tumor model. The results demonstrated that miR-141 expression was significantly decreased in tumor tissues compared with in healthy tissues (P |
| Databáze: | OpenAIRE |
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