Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell Proliferation and Invasion via Suppressing Sp1-Mediated EMT and Activation of Wnt/β-Catenin Signaling
| Autor: | Hongming Lu, Miao He, Kai Xu, Yu Sun, Guilian Fan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Epithelial-Mesenchymal Transition Glypican Sp1 Transcription Factor Proliferation Regulator Article law.invention 03 medical and health sciences Prostate cancer Invasion Glypicans Downregulation and upregulation law Cell Line Tumor medicine Glypican 5 (GPC5) Animals Humans Neoplasm Invasiveness Wnt Signaling Pathway Prostate cancer (PCa) Epithelial–mesenchymal transition (EMT) Cell Proliferation Mice Inbred BALB C Cell growth Chemistry Wnt signaling pathway Prostatic Neoplasms General Medicine medicine.disease Xenograft Model Antitumor Assays Up-Regulation 030104 developmental biology Oncology Cell culture Cancer research Suppressor |
| Zdroj: | Oncology Research |
| ISSN: | 0965-0407 |
| DOI: | 10.3727/096504017x15044461944385 |
| Popis: | Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a regulator of growth factors and morphogens. Recently, there have been reports on its correlation with the tumorigenic process in the development of some cancers. However, little is known about its precise role in prostate cancer (PCa). In the present study, we explored the expression pattern and biological functions of GPC5 in PCa cells. Our results showed that GPC5 was lowly expressed in PCa cell lines. Upregulation of GPC5 significantly inhibited PCa cell proliferation and invasion in vitro as well as attenuated tumor growth in vivo. We also found that overexpression of GPC5 inhibited the epithelial‐mesenchymal transition (EMT) and Wnt/β-catenin signaling activation, which was mediated by Sp1. Taken together, we suggest GPC5 as a tumor suppressor in PCa and provide promising therapeutic strategies for PCa. |
| Databáze: | OpenAIRE |
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