Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo

Autor: Hoff, Nicole A, Mukadi, Patrick, Doshi, Reena H, Bramble, Matthew S, Lu, Kai, Gadoth, Adva, Sinai, Cyrus, Spencer, D'Andre, Nicholson, Bradley P, Williams, Russell, Mossoko, Matthias, Ilunga-Kebela, Benoit, Wasiswa, Joseph, Okitolonda-Wemakoy, Emile, Alfonso, Vivian H, Steffen, Imke, Muyembe-Tamfum, Jean-Jacques, Simmons, Graham, Rimoin, Anne W
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
health care facilities
manpower
and services
serology
Disease
medicine.disease_cause
Medical and Health Sciences
Serology
Ebola virus
0302 clinical medicine
Seroepidemiologic Studies
Surveys and Questionnaires
80 and over
Immunology and Allergy
030212 general & internal medicine
Viral
Neutralizing
virus diseases
Middle Aged
Biological Sciences
Ebolavirus
3. Good health
Infectious Diseases
Democratic Republic of the Congo
Female
Infection
Adult
Health Personnel
education
and over
Microbiology
Virus
Antibodies
Vaccine Related
03 medical and health sciences
Young Adult
VP40
Biodefense
medicine
Seroprevalence
Humans
Aged
business.industry
healthcare workers
Prevention
Outbreak
Virology
030104 developmental biology
Emerging Infectious Diseases
Good Health and Well Being
Immunoglobulin G
business
Zdroj: The Journal of Infectious Diseases
The Journal of infectious diseases, vol 219, iss 4
ISSN: 1537-6613
0022-1899
DOI: 10.1093/infdis/jiy499
Popis: Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein: 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.
Databáze: OpenAIRE
Externí odkaz: