Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study
| Autor: | Toivo Rist, Keith H. Loven, Leonard J. Swinyer, Michael D. Baker, David L. Kaplan, John E. Wolf, Janusz Czernielewski, Stephen J. Kraus, Yin S Liu |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Administration Topical Dermatology Naphthalenes Severity of Illness Index Drug Administration Schedule law.invention Randomized controlled trial Reference Values Adapalene law Acne Vulgaris medicine Clindamycin Phosphate Humans Single-Blind Method Child Acne Probability Antibacterial agent Dose-Response Relationship Drug business.industry Clindamycin Middle Aged medicine.disease Treatment Outcome Tolerability Lotion Drug Therapy Combination Female business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of the American Academy of Dermatology. 49:S211-S217 |
| ISSN: | 0190-9622 |
| Popis: | This multicenter, randomized, investigator-blinded study investigated the efficacy and tolerability of adapalene gel 0.1% plus clindamycin phosphate lotion 1%, compared with clindamycin plus vehicle for the treatment of mild to moderate acne vulgaris. A total of 249 patients applied clindamycin lotion twice daily and adapalene (125 patients) or vehicle gel (124 patients) once daily for 12 weeks. A significantly greater reduction of total (P |
| Databáze: | OpenAIRE |
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