The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance
| Autor: | Rupa Sridharan, Khoa D. Tran, Caleb M. Dillingham |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Histone Demethylases
0301 basic medicine 030102 biochemistry & molecular biology JBC Reviews Cellular differentiation Induced Pluripotent Stem Cells Cell Biology DNA Methylation Biology Cellular Reprogramming Biochemistry Cell biology Chromatin 03 medical and health sciences 030104 developmental biology DNA demethylation Animals Humans Ketoglutaric Acids Epigenetics Stem cell Induced pluripotent stem cell Molecular Biology Reprogramming |
| Zdroj: | Journal of Biological Chemistry. 294:5408-5419 |
| ISSN: | 0021-9258 |
| Popis: | α-Ketoglutarate is an important metabolic intermediate that acts as a cofactor for several chromatin-modifying enzymes, including histone demethylases and the Tet family of enzymes that are involved in DNA demethylation. In this review, we focus on the function and genomic localization of these α-ketoglutarate–dependent enzymes in the maintenance of pluripotency during cellular reprogramming to induced pluripotent stem cells and in disruption of pluripotency during in vitro differentiation. The enzymatic function of many of these α-ketoglutarate–dependent proteins is required for pluripotency acquisition and maintenance. A better understanding of their specific function will be essential in furthering our knowledge of pluripotency. |
| Databáze: | OpenAIRE |
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