Selected functional outcomes in advanced oral cancer: Comparison of surgery alone versus surgery with postoperative radiotherapy

Autor: Ciaran Lane, Candace Myers, Deping Jiang, Andrew Cooke, Paul Kerr
Rok vydání: 2021
Předmět:
Zdroj: Head & Neck. 44:710-721
ISSN: 1097-0347
1043-3074
DOI: 10.1002/hed.26968
Popis: Study objectives were to determine whether the addition of postoperative radiation (PORT) resulted in a decline in oral function relative to surgery alone and to describe the longitudinal course of oral function following treatment of advanced oral cancer.This was a 36-month retrospectively analyzed observational cohort study of patients with stage III-IV oral cancer. Prospectively collected, oral functional outcomes were acquired pretreatment and 3, 6, 12, 24, and 36 months post-treatment.One hundred and eighteen patients were included. Forty-three patients treated with surgery alone were compared to 75 who received surgery with PORT. Mixed model analysis demonstrated the acute effect of PORT was associated with patient-rated xerostomia (p 0.001) and the late or persistent effect was associated with decreased clinician-rated eating in public (p = 0.008), understandability of speech (p = 0.02), and normalcy of diet (p = 0.005) compared with surgery alone. There were no differences between surgery alone and PORT groups in clinician-rated feeding tube dependence or patient-rated speech handicap.The use of PORT was associated with a demonstrable decline in oral function in four of six outcomes measures relative to surgery alone.
Databáze: OpenAIRE
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