Short-term statin treatment improves endothelial function and neurohormonal imbalance in normocholesterolaemic patients with non-ischaemic heart failure
| Autor: | C H Strey, Russell S. Scott, Arthur Mark Richards, J H Lainchbury, Joanna M. Young, M G Nicholls, Chris Frampton |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Statin Endothelium medicine.drug_class Atorvastatin Population Hemodynamics Cardiovascular Medicine chemistry.chemical_compound Double-Blind Method Internal medicine medicine Humans Pyrroles cardiovascular diseases Natriuretic Peptides education Heart Failure education.field_of_study Cross-Over Studies business.industry Cholesterol Middle Aged medicine.disease Vasodilation Editorial medicine.anatomical_structure Endocrinology chemistry Echocardiography Heptanoic Acids Heart failure cardiovascular system Vascular resistance Cardiology Female Vascular Resistance Endothelium Vascular Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Heart. 92:1603-1609 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.2005.082560 |
| Popis: | To investigate the effect of short-term statin treatment on impaired endothelium-dependent vasodilatation and haemodynamic abnormalities typically occurring in chronic heart failure (CHF).In a double-blind, crossover study endothelium-dependent vasodilatation was measured in conduit and resistance vessels of 23 patients with non-ischaemic CHF after 6 weeks of placebo and 40 mg atorvastatin. The haemodynamic impact was assessed by cardioendocrine hormones, echocardiography and clinical indicators of CHF.Cholesterol concentrations were population average (low density lipoprotein 3.56 (SEM 0.16) mmol/l, triglycerides 1.70 (0.20) mmol/l and high density lipoprotein 1.17 (0.07) mmol/l). In resistance vessels, the area under the curve ratio during acetylcholine infusion increased from 9.2 (1.9) with placebo to 12.2 (2.1) with statin (p0.01). This improvement was reversed during co-infusion with the nitric oxide antagonist N(G)-monomethyl-L-arginine. In conduit arteries, flow-mediated dilatation increased from 5.64 (SEM 0.88)% with placebo to 6.83 (0.97)% with statin (p0.05). Endothelium-independent vasodilatation did not change (p = 0.68 for conduit and p = 0.45 for resistance vessels). Endothelin 1 and atrial natriuretic peptide (ANP) decreased from 1.57 (0.08) and 51.3 (1.0) with placebo to 1.42 (0.09) pg/ml (p0.05) and 42.1 (7.5) pmol/l (p0.05), respectively, with statin.In patients with non-ischaemic CHF and population-average cholesterol concentrations, short-term statin treatment improves endothelial function in conduit and resistance vessels and lowers plasma endothelin 1 and ANP concentrations. |
| Databáze: | OpenAIRE |
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