A novel combined prognostic nutritional index and aspartate aminotransferase-to-platelet ratio index-based score can predict the survival of patients with hepatocellular carcinoma who undergo hepatic resection

Autor: Kyohei, Yugawa, Takashi, Maeda, Shigeyuki, Nagata, Akihiro, Sakai, Makoto, Edagawa, Takahiro, Omine, Takuro, Kometani, Shohei, Yamaguchi, Kozo, Konishi, Kenkichi, Hashimoto
Rok vydání: 2022
Předmět:
Zdroj: Surgery Today. 52:1096-1108
ISSN: 1436-2813
0941-1291
Popis: Inflammation-, nutrition-, and liver fibrosis-related markers are recognized as prognostic for hepatocellular carcinoma (HCC) patients. This study, therefore, assessed the preoperative prognostic utility of the combination of these markers in patients with HCC.This single-center retrospective study included patients who underwent hepatic resection for HCC between 2004 and 2017. A total of 454 patients were divided into training (n = 334) and validation (n = 120) cohorts by random sampling. The predictive impact on surgical outcomes was evaluated using receiver operating characteristic (ROC) curves of these prognostic values in the training cohort.The prognostic nutritional index (PNI) and aspartate aminotransferase-to-platelet ratio index (APRI) were the strongest diagnostic values (areas under the ROC curves: 0.627 and 0.646, respectively). A scoring system (over 0-2 points) was developed using optimal cutoff values (for PNI 46.5 scored as 1 point; for APRI 0.98 scored as 1 point). An increased PNI-APRI score was an independent prognostic factor for both the overall and disease-free survival in HCC patients. Finally, the clinical feasibility of the PNI-APRI score was confirmed in the validation cohort.The PNI-APRI score is a useful marker for predicting surgical outcomes of HCC patients.
Databáze: OpenAIRE
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