Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes
| Autor: | Fort, Kyle L, van de Waterbeemd, Michiel, Boll, Dmitriy, Reinhardt-Szyba, Maria, Belov, Mikhail E, Sasaki, Eita, Zschoche, Reinhard, Hilvert, Donald, Makarov, Alexander A, Heck, Albert J R, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics |
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| Přispěvatelé: | Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chromatography Chemistry Analytical chemistry 010402 general chemistry Orbitrap Mass spectrometry 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry law.invention 03 medical and health sciences 030104 developmental biology law Q exactive Electrochemistry Macromolecular Complexes Environmental Chemistry Signal intensity Spectroscopy |
| Zdroj: | The Analyst The Analyst, 143(1), 100. Royal Society of Chemistry |
| ISSN: | 1364-5528 0003-2654 |
| Popis: | Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described. |
| Databáze: | OpenAIRE |
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