Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France
| Autor: | E K, Déti, R, Thiébaut, F, Bonnet, S, Lawson-Ayayi, M, Dupon, D, Neau, J L, Pellegrin, D, Malvy, S, Tchamgoué, F, Dabis, P, Morlat, D, Touchard |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Anti-HIV Agents Organophosphonates Prevalence Renal function HIV Infections Indinavir Kidney Kidney Function Tests Body Mass Index chemistry.chemical_compound Pharmacotherapy Internal medicine Epidemiology Humans Medicine Pharmacology (medical) Renal Insufficiency Stage (cooking) Tenofovir Creatinine business.industry Adenine Health Policy Middle Aged CD4 Lymphocyte Count Infectious Diseases chemistry Hypertension Cohort Immunology Female France Epidemiologic Methods business Body mass index |
| Zdroj: | HIV Medicine. 11:308-317 |
| ISSN: | 1468-1293 1464-2662 |
| Popis: | The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV-infected adult patients and to investigate the associated factors.A cross-sectional survey was conducted in a French hospital-based cohort. Clearance of creatinine (CC) was calculated using the Cockcroft-Gault formula. Four stages of RI were defined: mild (60-90 mL/min), moderate (30-60), severe (15-30) and end stage (15). Logistic regression models were used to investigate factors associated with RI.The male/female ratio of the 2588 patients enrolled was 3:1 and the median age was 42 years. At the time of assessment of CC, the median CD4 count was 430 cells/microL and HIV plasma viral load (VL) was50 copies/mL in 60%. The overall prevalence of RI was 39.0%: 34.2% mild, 4.4% moderate, 0.3% severe and 0.2% end-stage. Mild RI was associated with female gender [odds ratio (OR)=3.3: 95% CI 2.6-4.3)], age50 years (OR=9.8: 7.4-13.0) and 40-50 years (OR=1.9: 1.5-2.4), body mass index (BMI)22 kg/m(2) (OR=3.3: 2.7-4.3) and tenofovir exposure (OR=1.4: 1.0-1.9 for1 year and OR=1.5: 1.2-2.0 for1 year). Advanced RI (CC60 mL/min) was associated with age50 years (OR=5.6: 2.9-10.9) and 40-50 years (OR=2.2: 1.1-1.4), BMI22 kg/m(2) (OR=1.5: 1.0-2.4), hypertension (OR=2.5: 1.4-2.5) and indinavir (IDV) exposure1 year (OR=2.3: 1.5-3.6).This survey confirms the high prevalence of RI in HIV-infected patients and indicates the importance of the investigation of renal function especially in women, older patients, those with a low BMI or treated with tenofovir or IDV. |
| Databáze: | OpenAIRE |
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