Tissue architecture in tumor initiation and progression
| Autor: | Jorge Almagro, Hendrik A. Messal, Alberto Elosegui-Artola, Jacco van Rheenen, Axel Behrens |
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| Rok vydání: | 2022 |
| Předmět: |
Model organisms
Cancer Research Stem Cells Genome Integrity & Repair Gene Expression Cell Biology Tumour Biology Imaging Signalling & Oncogenes Cell Transformation Neoplastic Oncology Neoplasms Tumor Microenvironment Humans Microfabrication & Bioengineering Stromal Cells Genetics & Genomics Developmental Biology Structural Biology & Biophysics Computational & Systems Biology |
| DOI: | 10.25418/crick.19890367 |
| Popis: | The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells. |
| Databáze: | OpenAIRE |
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