| Autor: |
Roger Pocock, Jakob Gramstrup Petersen |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Worm. 2:e27284 |
| ISSN: |
2162-4054 |
| DOI: |
10.4161/worm.27284 |
| Popis: |
We recently conducted a study that aimed to describe the differentiation mechanisms used to generate O2 and CO2 sensing neurons in C. elegans. We identified egl-13/Sox5 to be required for the differentiation of both O2 and CO2 sensing neurons. We found that egl-13 functions cell autonomously to drive O2 and CO2 sensing neuron fate and is therefore essential for O2 and CO2 sensing-induced behaviors. Through systematic dissection of the egl-13 promoter we identified upstream regulators of egl-13 and proposed a model of how differentiation of O2 and CO2 sensing neurons is regulated. In this commentary we discuss our findings and open questions we wish to address in future studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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