Adrenergic regulation of adipocyte metabolism

Autor: Christian Carpéné, Max Lafontan, Jean Galitzky, P. Barbe, Dominique Langin, Michel Berlan, Alain Bousquet-Mélou, Geneviève Tavernier
Přispěvatelé: Bousquet-Mélou, Alain
Rok vydání: 1997
Předmět:
Beta-3 adrenergic receptor
medicine.medical_specialty
Adrenergic receptor
Lipolysis
MESH: Receptors
Adrenergic
Alpha (ethology)
MESH: Lactates
030209 endocrinology & metabolism
White adipose tissue
Biology
03 medical and health sciences
chemistry.chemical_compound
Catecholamines
0302 clinical medicine
Internal medicine
Adipocyte
Adipocytes
MESH: Catecholamines
medicine
Humans
MESH: Lipolysis
Beta (finance)
MESH: Adipocytes
030304 developmental biology
0303 health sciences
MESH: Humans
Rehabilitation
Obstetrics and Gynecology
Receptors
Adrenergic
MESH: Glucose
Lipoprotein Lipase
Glucose
Endocrinology
Reproductive Medicine
chemistry
3'
5'-Cyclic-AMP Phosphodiesterases
MESH: 3'
5'-Cyclic-AMP Phosphodiesterases
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Lactates
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Alpha-2 adrenergic receptor
MESH: Lipoprotein Lipase
Zdroj: Human Reproduction
Human Reproduction, Oxford University Press (OUP), 1997, 12 Suppl 1, pp.6-20
Europe PubMed Central
ISSN: 1460-2350
0268-1161
DOI: 10.1093/humrep/12.suppl_1.6
Popis: International audience; Five adrenoceptor (AR) subtypes (beta 1, beta 2, beta 3, alpha 2 and alpha 1), are involved in the control of white and brown fat cell function. A number of metabolic events are controlled by the adrenergic system in fat cells. The stimulatory effect of catecholamines on lipolysis and metabolism is mainly connected to increments in cAMP levels, cAMP protein kinase activation and phosphorylation of various target proteins. Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 > beta 1 > or = beta 2 > beta 3 for norepinephrine). Antagonistic actions at the level of cAMP production exist between alpha 2- and beta 1-, beta 2- and beta 3-AR-mediated lipolytic effects in human white fat cells. The role of fat cell alpha 2-ARs, which largely outnumber beta-ARs in fat cells of certain fat deposits, in human and primate has never been clearly understood. The other AR type which is not linked to lipolysis regulation, the alpha 1-AR, is involved in the control of glycogenolysis and lactate production. Pharmacological approaches using in-situ microdialysis and selective alpha 2- and beta-AR agonists and antagonists have revealed sex- and tissue-specific differences in the adrenergic control of fat cell function and nutritive blood flow in the tissue surrounding the microdialysis probe.
Databáze: OpenAIRE
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