Interferon-inducible protein 16 may be a biomarker and prognostic factor in renal cell carcinoma by bioinformatics analysis
| Autor: | Baozhong Yu, Peng Cao, Jiandong Zhang, Feilong Zhang, Wei Wang, Xiang Zheng, Zejia Sun, Haoyuan Cao, Zihao Gao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
renal cell carcinoma
Databases Factual mRNA Chromophobe cell Disease-Free Survival Immune system Renal cell carcinoma Biomarkers Tumor Carcinoma Humans Medicine Carcinoma Renal Cell Kidney Oncogene business.industry Computational Biology Nuclear Proteins biomarkers Clinical Trial/Experimental Study General Medicine Phosphoproteins Prognosis medicine.disease Kidney Neoplasms immune infiltrates medicine.anatomical_structure Neutrophil degranulation Cancer research Biomarker (medicine) business interferon-inducible protein 16 Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000024257 |
| Popis: | Background: Renal cell carcinoma (RCC) accounts for 2% to 3% of all human malignancies and is the 9th most common malignancy in Western countries. Due to the development of surgical procedures and the use of novel drugs, survival has been significantly prolonged. However, current challenges include how to diagnose RCC earlier and how to overcome drug resistance. Methods: We explored the relationship between the transcription level of IFI16 and clinical data in RCC through various online databases, including ONCOMINE, GEPIA, HPA, Timer and COEXPEDIA. Results: In comparison with corresponding normal tissues, IFI16 mRNA expression levels were higher in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) tissues. In KIRC, the higher expression of IFI16 was associated with lower overall survival (P = .037). In KIRP, the higher expression IFI16 was associated with lower disease-free survival and overall survival (P = .037 and P = .011). In contrast, the IFI16 expression was negatively correlated with tumor purity in kidney chromophobe, KIRC and KIRP (all P |
| Databáze: | OpenAIRE |
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