Prevalence of acromegaly in patients with symptoms of sleep apnea
| Autor: | Sesmilo, Gemma, Resmini, Eugenia, Sambo, Marcel, Blanco, Concepción, Calvo, Fernando, Pazos, Fernando, Fernández-Catalina, Pablo, Martínez de Icaya, Purificación, Páramo, Concepción, Fajardo, Carmen, Marazuela Azpiroz, Mónica, Álvarez Escolá, María Cristina, Díez Gómez, Juan José, Perea, Verónica, ACROSAHS study group |
|---|---|
| Přispěvatelé: | UAM. Departamento de Medicina, Instituto de Investigación del Hospital de La Princesa (IP) |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics Pulmonology Apnea Peptide Hormones lcsh:Medicine Biochemistry Nervous System Diagnostic Radiology 0302 clinical medicine Endocrinology Epidemiology Medicine and Health Sciences Prevalence 030212 general & internal medicine Insulin-Like Growth Factor I lcsh:Science Multidisciplinary medicine.diagnostic_test Radiology and Imaging Sleep apnea Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Neurology Pituitary Gland Female Anatomy Research Article Adult medicine.medical_specialty Sleep Apnea Patients Endocrine Disorders Imaging Techniques Medicina 030209 endocrinology & metabolism Endocrine System Research and Analysis Methods 03 medical and health sciences Sleep Apnea Syndromes Tongue Diagnostic Medicine Diabetes mellitus Acromegaly medicine Diabetes Mellitus Humans sleep apnea symptom Carpal tunnel syndrome Aged Mouth Health Care Policy business.industry lcsh:R Biology and Life Sciences Magnetic resonance imaging medicine.disease Hormones Health Care Neuroanatomy Spain Growth Hormone Metabolic Disorders Symptoms lcsh:Q business Sleep Disorders Digestive System Biomarkers Screening Guidelines Rare disease Neuroscience |
| Zdroj: | Biblos-e Archivo. Repositorio Institucional de la UAM instname PLoS One r-FISABIO. Repositorio Institucional de Producción Científica PLoS ONE Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona PLoS ONE, Vol 12, Iss 9, p e0183539 (2017) Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| ISSN: | 1932-6203 |
| Popis: | Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40–125 cases/million but targeted universal screening studies have found a higher prevalence (about 10 fold). The aim of the ACROSAHS study was to investigate the prevalence of acromegaly and acromegaly comorbidities in patients with sleep apnea symptoms and acral enlargement. ACROSAHS was a Spanish prospective non-interventional epidemiological study in 13 Hospital sleep referral units. Facial and acral enlargement symptoms including: ring size and shoe size increase, tongue, lips and jaws enlargement, paresthesia or carpal tunnel syndrome and widening of tooth spaces, as well as other typical acromegaly comorbidities were recorded with a self-administered questionnaire of patients who attended a first visit for sleep apnea symptoms between 09/2013 and 07/2014. Serum insulin-like growth factor type 1 (IGF1) was measured in patients with ≥1 acral symptom to determine the prevalence of acromegaly. Of the 1557 patients enrolled, 1477 with complete data (72% male) were analyzed. 530 patients (36%) reported at least 1 acral enlargement symptom and were tested for IGF-1, 41 were above range, persisted in 7, and among those, 2 cases of acromegaly were diagnosed (prevalence of at least 1.35 cases/1000). Overall, 1019 patients (69%) had ≥2 acromegaly symptoms and should have been screened according to guidelines; moreover 373 patients (25%) had ≥1 symptom of acral enlargement plus ≥3 other acromegaly symptoms. In conclusion, in patients with sleep apnea symptoms and acral enlargement, we found an acromegaly prevalence of at least 1.35 cases per 1000 and a high prevalence of typical acromegaly symptoms. It is important that sleep specialists are aware of acromegaly symptoms to aid with acromegaly diagnosis. The study was investigator initiated and was partially sponsored by Ipsen Pharma, S.A., Spain |
| Databáze: | OpenAIRE |
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