Prospective associations between lateralised brain function and immune status in HIV infection: Analysis of EEG, cognition and mood over 30 months
| Autor: | Susan Catt, Gillian Irving, Torsten Baldeweg, David Hawkins, John Gruzelier, Jose Catalan, Janet Stygall, Massimo Riccio, Adrian Burgess |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty CD4-CD8 Ratio HIV Infections Neuropsychological Tests Audiology Electroencephalography Functional Laterality Lateralization of brain function Developmental psychology Cognition Double-Blind Method Physiology (medical) medicine Humans Semantic memory Longitudinal Studies Prospective Studies Recognition memory medicine.diagnostic_test General Neuroscience Neuropsychology Brain Affect Neuropsychology and Physiological Psychology Mood Laterality Psychology |
| Zdroj: | International Journal of Psychophysiology. 23:215-224 |
| ISSN: | 0167-8760 |
| DOI: | 10.1016/s0167-8760(96)00064-5 |
| Popis: | Prospective relations between individual differences in both lateralised neuro-psychophysiological functions and mood ratings with immune status (CD4 and CD8 counts) were examined in asymptomatic HIV-positive men (n = 27) over thirty months. They participated in a controlled study of zidovudine versus placebo (results published elsewhere). Measures included EEG spectra, neuropsychological tests and mood ratings. A model of reciprocal lateralised influences on the immune system was tested whereby patients with left superior to right hemispheric functions were predicted to show a less deleterious outcome than those with the opposite asymmetry pattern. Prospective relations with immune status were found in the EEG with lateralised theta, alpha and betaI activity; among cognitive measures with word fluency, semantic processing, and lateralised motor and recognition memory (word/face) processes; with mood ratings including depression, confusion and the total mood score. The nature of the effects supported the laterality predictions. These unique data, showing that neuro-psychophysiological factors in HIV + but otherwise healthy subjects predict immune competence and compromise present 2–3 years later, warrant replication in a larger cohort. |
| Databáze: | OpenAIRE |
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