Occult hepatitis B virus in liver tissue of individuals without hepatic disease
| Autor: | C. Scisca, Lucy Costantino, Gaetano Di Vita, Giovanni Raimondo, Stefania Mondello, Teresa Pollicino, Giovanni Squadrito, Eugenio Cucinotta, Guido Colloredo, Giuseppe Navarra |
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| Přispěvatelé: | Raimondo, G, Navarra, G, Mondello, S, Costantino, L, Colloredo, G, Cucinotta, E, Di Vita, GG, Scisca, C, Squadrito, G, Pollicino, T |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hepatitis B virus HBsAg Hepatitis C virus Population hepatitis B virus liver tissue medicine.disease_cause Liver disease Normal liver Orthohepadnavirus Occult HBV HBV DNA Anti-HBc HBV-seronegative medicine Humans Hepatitis B Antibodies education Aged education.field_of_study Hepatology biology business.industry virus diseases Middle Aged Hepatitis B medicine.disease biology.organism_classification Hepatitis B Core Antigens Occult digestive system diseases Liver Hepadnaviridae Carrier State DNA Viral Immunology Female business |
| Zdroj: | Journal of Hepatology. 48:743-746 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/j.jhep.2008.01.023 |
| Popis: | BACKGROUND/AIMS: While many data are available concerning occult hepatitis B virus (HBV) infection in patients with hepatic disorders, there is little information about this cryptic infection in individuals without liver disease. The aim of this study was to investigate the prevalence of occult HBV in the general population by examining liver specimens from a large series of HBV-surface-antigen negative individuals with no clinical and biochemical evidence of liver disease. METHODS: The presence of HBV DNA was evaluated by testing, through polymerase chain reaction techniques, DNA extracts from 98 liver-disease-free individuals who underwent liver resection or needle biopsy during abdominal surgery. Sixteen of them were anti-HBV-core antigen (anti-HBc) positive and 82 were HBV serum-marker negative. All patients were negative for antibody to hepatitis C virus. RESULTS: Occult HBV infection was revealed in 16 of the 98 cases (16.3%). In particular, 10/16 anti-HBc positive (62.5%) versus 6/82 (7.3%) HBV-seronegative individuals were occult carriers (p |
| Databáze: | OpenAIRE |
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