Risk factors for pancreatic stone formation in autoimmune pancreatitis over a long-term course
| Autor: | Masafumi Maruyama, Hideaki Hamano, Akihiro Matsumoto, Takashi Muraki, Masahiro Maruyama, Tetsuya Ito, Takayuki Watanabe, Yayoi Ozaki, Shigeyuki Kawa, Suguru Yoneda, Norikazu Arakura |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Prednisolone Constriction Pathologic Wirsung duct Gastroenterology Calculi Autoimmune Diseases Santorini duct Risk Factors Internal medicine medicine Humans Risk factor Glucocorticoids Autoimmune pancreatitis Aged Aged 80 and over Cholangiopancreatography Endoscopic Retrograde Univariate analysis Endoscopic retrograde cholangiopancreatography medicine.diagnostic_test business.industry Pancreatic Ducts Pancreatic Diseases Pancreatic stone Middle Aged Hepatology medicine.disease Colorectal surgery Pancreatitis Pancreatic juice Female Tomography X-Ray Computed business Follow-Up Studies Abdominal surgery |
| Zdroj: | Journal of Gastroenterology. 47:553-560 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s00535-011-0510-y |
| Popis: | Autoimmune pancreatitis (AIP) has the potential to progress to a chronic state that forms pancreatic stones. The aim of this study was to clarify the risk factors underlying pancreatic stone formation in AIP. Sixty-nine patients with AIP who had been followed for at least 3 years were enrolled for evaluation of clinical and laboratory factors as well as computed tomography and endoscopic retrograde cholangiopancreatography findings. During the course of this study, increased or de novo stone formation was seen in 28 patients, who were defined as the stone-forming group. No stones were observed in 32 patients, who were defined as the non-stone-forming group. Nine patients who had stones at diagnosis but showed no change during the course of this study were excluded from our cohort. Univariate analysis revealed no significant differences in clinical or laboratory factors associated with AIP-specific inflammation between the two groups. However, pancreatic head swelling (P = 0.006) and narrowing of both Wirsung's and Santorini's ducts in the pancreatic head region (P = 0.010) were significantly more frequent in the stone-forming group. Furthermore, multivariate analysis identified Wirsung and Santorini duct narrowing at diagnosis as a significant independent risk factor for pancreatic stone formation (OR 4.4, P = 0.019). A primary risk factor for pancreatic stone formation in AIP was narrowing of both Wirsung's and Santorini's ducts, which most presumably led to pancreatic juice stasis and stone development. Article JOURNAL OF GASTROENTEROLOGY. 47(5):553-560 (2012) |
| Databáze: | OpenAIRE |
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