Epidemiology of Soft Tissue Sarcoma and Bone Sarcoma inItaly: Analysis of Data from 15 Population-Based Cancer Registries

Autor: Francesca Ferrari, Giulio Barigelletti, Maria Michiara, Giuliano Carrozzi, Antonio Ardizzone, Isabella Bisceglia, Guido Mazzoleni, Lucia Mangone, Giovanna Tagliabue, AnnaClara Fanetti, Eugenia Spata, Sabrina Fabiano, Andrea Tittarelli, F Pala, Fabio Vittadello, Marine Castaing, llaria Fontanili, T Intrieri, Anna Maghini, Francesca Bella, Lucia Elena De Lorenzis, Antonella Puppo, Claudia Casella, Lorenza Boschetti, Claudia Cirilli, Gianfranco Manneschi, Salvatore Sciacca, Giovanna Maria Sini, Ivan Cometti, Paolo Contiero, Maurizio Castelli, Anna D’Agostino, Salvatore Bongiorno, Rosario Tumino, Ylenia M Dinaro, Simona Migliazza
Rok vydání: 2020
Předmět:
Zdroj: Sarcoma, Vol 2020 (2020)
ISSN: 1369-1643
1357-714X
DOI: 10.1155/2020/6142613
Popis: Sarcomas are a heterogeneous group of rare cancers of mesenchymal origin. In this study, we provide updated, world age-standardised incidence rate (ASR) and European age-standardised incidence rate for malignant soft tissue sarcoma (ICD-O-3 topographic code C47–C49) and bone sarcoma (C40, C41) in Italy, by area (north, centre, and south) and by cancer registry. We also assess morphology in relation to site and area and assess metastases at diagnosis. We analysed 1,112 cases, with incidence 2009–2012, provided by 15 cancer registries (CRs) affiliated to the Association of Italian Cancer Registries (AIRTUM). Overall, ASR was 1.7/100,000/year for soft tissue sarcoma and 0.7 for bone sarcoma. Central Italy had the highest (2.4) ASR and south Italy had the lowest (1.6) ASR for soft tissue sarcoma. Central Italy had the highest (1.1) ASR and north Italy had the lowest (0.7) ASR for bone sarcoma. By CR, ASRs ranged from 1.1 to 2.6 for soft tissue sarcoma and from 0 to 1.4 for bone sarcoma. The most frequent soft tissue sarcomas were sarcoma not otherwise specified (NOS) (29.4%) and liposarcoma (22.2%); the most common bone sarcoma was chondrosarcoma (37.6%). Soft tissue sarcomas occurred most frequently (35.6%) in lower limb connective tissue; bone sarcomas arose mainly (68.8%) in long bones. The frequencies of morphologies arising at different sites varied considerably by Italian area; for example, 20% of hemangiosarcomas occurred in the head and neck in south Italy with 17% at this site in the centre and 6% in the north. For soft tissue sarcoma, the highest ASRs of 2.6 and 2.4 contrast with the lowest ASRs 1.1 and 1.3, suggesting high-risk hot spots that deserve further investigation. The marked variations in morphology distribution with site and geography suggest geographic variation in risk factors that may also repay further investigation particularly since sarcoma etiology is poorly understood.
Databáze: OpenAIRE
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