When stable RNA becomes unstable: the degradation of ribosomes in bacteria and beyond
| Autor: | Tanel Tenson, Ülo Maiväli, Anton Paier |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Genetics
Clinical Biochemistry Saccharomyces cerevisiae RNA Biology Ribosomal RNA biology.organism_classification medicine.disease_cause Biochemistry Ribosome Yeast RNA Ribosomal Biophysics medicine Escherichia coli Degradation (geology) RNA Processing Post-Transcriptional Molecular Biology Ribosomes Bacteria |
| Zdroj: | Biological chemistry. 394(7) |
| ISSN: | 1437-4315 |
| Popis: | This review takes a comparative look at the various scenarios where ribosomes are degraded in bacteria and eukaryotes with emphasis on studies involving Escherichia coli and Saccharomyces cerevisiae. While the molecular mechanisms of degradation in bacteria and yeast appear somewhat different, we argue that the underlying causes of ribosome degradation are remarkably similar. In both model organisms during ribosomal assembly, partially formed pre-ribosomal particles can be degraded by at least two different sequentially-acting quality control pathways and fully assembled but functionally faulty ribosomes can be degraded in a separate quality control pathway. In addition, ribosomes that are both structurally- and functionally-sound can be degraded as an adaptive measure to stress. |
| Databáze: | OpenAIRE |
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