Muscle mass and functional correlates of insulin sensitivity in lean young Indian men
| Autor: | Anura V Kurpad, R P Kishore, Mario Vaz, Uma S. Unni, Tinku Thomas, G. Ramakrishnan, Tony Raj |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent medicine.medical_treatment Medicine (miscellaneous) Body Mass Index Young Adult Absorptiometry Photon Oxygen Consumption Insulin resistance Asian People Internal medicine Diabetes mellitus medicine Hyperinsulinemia Humans Insulin Muscle Strength Muscle Skeletal Nutrition and Dietetics business.industry Skeletal muscle Calorimetry Indirect Glucose clamp technique medicine.disease Endocrinology medicine.anatomical_structure Quartile Body Composition Glucose Clamp Technique Insulin Resistance business Body mass index |
| Zdroj: | European Journal of Clinical Nutrition. 63:1206-1212 |
| ISSN: | 1476-5640 0954-3007 |
| Popis: | BACKGROUND/OBJECTIVES There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important site of glucose disposal, the strength of its association with insulin sensitivity (IS) is unknown in the Indian population. SUBJECTS/METHODS This was a cross-sectional study performed to assess the association of body fat, muscle and muscle function with IS in 51 young, healthy, nonobese Indian men with BMI ranging from 15 to 25 kg/m(2), using hyperinsulinemic euglycemic clamp method. RESULTS The median IS was 5.32 (mg/(kg min))/(microU/ml), lower, upper quartile, 4.03, 6.56); (SI units: 4.25, lower, upper quartile, 3.22, 5.24 (micromol/(kg min))/(pmol/l)). A multiple linear regression of the natural log transformed value of IS on BMI and body muscle mass measured as the appendicular lean soft tissue (expressed as a percentage of body weight) explained 49% of the variance in IS. Independently, body fat percent and muscle (handgrip) strength showed significant bivariate correlations with IS (rho=-0.61, P |
| Databáze: | OpenAIRE |
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