UNDERSTANDING TISSUE-ENGINEERED ENDOCHONDRAL OSSIFICATION; TOWARDS IMPROVED BONE FORMATION
| Autor: | Eric Farrell, Callie Knuth, Eppo B. Wolvius, Roberto Narcisi, Caoimhe H. Kiernan |
|---|---|
| Přispěvatelé: | Oral and Maxillofacial Surgery, Orthopedics and Sports Medicine |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Diseases of the musculoskeletal system
0206 medical engineering lcsh:Surgery regenerative medicine 02 engineering and technology Regenerative medicine Bone and Bones Extracellular matrix Tissue engineering Osteogenesis Animals Humans Medicine Bone formation bone tissue engineering Process (anatomy) Endochondral ossification Tissue Engineering business.industry vascularisation Mesenchymal stem cell Mesenchymal Stem Cells lcsh:RD1-811 020601 biomedical engineering mesenchymal stem cell differentiation Extracellular Matrix Cell biology immune system Bone Substitutes collagen type X Mesenchymal stem cell differentiation lcsh:RC925-935 business |
| Zdroj: | European Cells & Materials, Vol 37, Pp 277-291 (2019) European cells & materials, 37, 277-291. AO Research Institute |
| ISSN: | 1473-2262 |
| Popis: | Endochondral ossification (EO) is the process by which the long bones of the body form and has proven to be a promising method in tissue engineering for achieving cell-mediated bone formation. The present review centred on state-of-the-art research pertaining to mesenchymal stem cells (MSCs)-mediated endochondral bone formation, focusing on the role of donor cells, extracellular matrix and host immune cells during tissue-engineered bone formation. Possible research avenues to improve graft outcome and bone output were highlighted, as well as emerging research that, when applied to tissue-engineered bone grafts, offers new promise for improving the likelihood of such grafts transition from bench to bedside. |
| Databáze: | OpenAIRE |
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