Paclitaxel-induced interstitial pneumonia after drug-eluting stent implantation: report of a fatal case
| Autor: | Toshiyuki Mori, Kiyoshi Yokoi, Yuko Takano, Satoshi Fukuda, Kiyoyasu Yamada, Tetsuo Fujimaki, Susumu Suzuki, Kazuko Watanabe, Ken Kato, Kimihiko Kato, Eiji Kunii |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Paclitaxel Pulmonary toxicity medicine.medical_treatment Autopsy Angina Prosthesis Implantation chemistry.chemical_compound Fatal Outcome Restenosis Internal medicine Internal Medicine medicine Humans Interstitial pneumonia cardiovascular diseases Adverse effect Aged business.industry Drug-Eluting Stents General Medicine equipment and supplies medicine.disease Surgery chemistry Drug-eluting stent Cardiology business Lung Diseases Interstitial |
| Zdroj: | Internal medicine (Tokyo, Japan). 48(11) |
| ISSN: | 1349-7235 |
| Popis: | We report a case of paclitaxel-eluting stent implantation in an angina patient who developed interstitial pneumonia a few days afterward, and succumbed to fatal respiratory dysfunction despite corticosteroid therapy. Paclitaxel is an anti-neoplastic agent currently used as a coating substance for coronary stents to reduce the rate of restenosis. Pulmonary toxicity related to paclitaxel is not very common; however, this adverse event may on occasion be lethal. Although the efficacy and safety of drug-eluting stents for the treatment of ischemic heart disease is well established, physicians should keep in mind that paclitaxel-eluting stents have the potential to cause interstitial pneumonia. |
| Databáze: | OpenAIRE |
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