Kinetic analysis of rubidium and thallium as deposited myocardial blood flow tracers in isolated rabbit heart
| Autor: | Pamela G. Coxson, A. Kuruc, Thomas F. Budinger, Ronald H. Huesman, Scott E. Taylor, Patricia Powers-Risius, Robert C. Marshall, Bryan W. Reutter |
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| Rok vydání: | 1997 |
| Předmět: |
Erythrocytes
Time Factors Physiology chemistry.chemical_element In Vitro Techniques Isotopes of rubidium Rubidium Coronary circulation Physiology (medical) TRACER Coronary Circulation medicine Animals Radionuclide Imaging business.industry Myocardium Models Cardiovascular Heart Blood flow Kinetics Thallium Radioisotopes medicine.anatomical_structure chemistry Regional Blood Flow Thallium Rabbits Cardiology and Cardiovascular Medicine Nuclear medicine business Perfusion Rubidium Radioisotopes Biomedical engineering |
| Zdroj: | The American journal of physiology. 272(3 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | Evaluation of myocardial perfusion with tracers such as thallium and rubidium is based on the assumption that tissue tracer content is proportional to flow. The purpose of this study was to evaluate the relationship between flow and tissue tracer content of 201Tl and 83Rb in the isolated perfused rabbit heart. 83Rb (86-day half-life), an isotope that is not used clinically, was used as a subsitute for 82Rb (76-s half-life) to improve the accuracy and precision of data acquisition. The multiple indicator-dilution technique was employed with two independent computational approaches. The first approach explicitly deconvolved 201Tl and 83Rb venous concentration curves by the intravascular reference tracer curve. The second approach used a conventional analysis. Both approaches showed that there was more early washout of 83Rb than 201Tl and that the heart retained 201Tl better than 83Rb within 2 min after isotope introduction. These data indicate that 201Tl is a better perfusion tracer than 83Rb in the isolated rabbit heart. |
| Databáze: | OpenAIRE |
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