Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle
| Autor: | Artur Dzik, Jonatas Borges Soares, David B. Seifer, Vicente Mario Izzo, Geralyn Lambert-Messerlian, José Aristodemo Pinotti |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Time Factors medicine.drug_class medicine.medical_treatment Fertilization in Vitro Biology Specimen Handling Andrology Follicle-stimulating hormone medicine Humans Ovarian reserve Ovarian Function Tests Retrospective Studies Gynecology In vitro fertilisation Estradiol Prostatic Secretory Proteins Obstetrics and Gynecology Odds ratio Oocyte female genital diseases and pregnancy complications Treatment Outcome medicine.anatomical_structure Reproductive Medicine Estrogen Oocytes Female Follicle Stimulating Hormone Gonadotropin Peptides hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Fertility and Sterility. 74:1114-1117 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(00)01627-7 |
| Popis: | Objective: To examine whether the magnitude of the rise in inhibin B levels after gonadotropin challenge is associated with subsequent response to ovarian stimulation during IVF. Design: Inhibin B serum levels after EFORT (exogenous follicle-stimulating hormone ovarian reserve test). Setting: Academic clinical practice. Patient(s): Serum samples from women who had undergone ovarian reserve screening with FSH in preparation for IVF. Thirteen of these women had a poor response in IVF (canceled cycle for low estradiol and/or no oocytes retrieved), and 19 had a good response (≥10 oocytes retrieved). Intervention(s): EFORT test. Main Outcome Measure(s): Baseline (day 3) serum E 2 (bE 2 ), FSH (bFSH), and inhibin B (bInhB) levels and inhibin B and E 2 levels 24 hours after EFORT (ΔInhB and ΔE 2 ). Result(s): The mean bInhB and ΔInhB levels were significantly higher in good vs. poor responders. The odds ratio of having a good response for women with a ΔInhB of 202 pg/mL was 51.8 times (95% CI=6.1–1,244) the corresponding odds for women with a ΔInhB of 49 pg/mL. As expected, ΔE 2 was also significantly higher in good vs. poor responders; however, combination of ΔE 2 plus ΔInhB did not improve the odds for predicting IVF response. Conclusion(s): Our data suggest that ΔInhB after EFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle. |
| Databáze: | OpenAIRE |
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