Inhibin as a marker for hydatidiform mole: a comparative study with the determinations of intact human chorionic gonadotrophin and its free β-subunit
| Autor: | E. Poncelet, Y. Badonnel, H. Legagneur, M. Schweitzer, F Barbé |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Spontaneous remission Biology Peptide hormone Chorionic Gonadotropin Immunoenzyme Techniques Endocrinology Pregnancy Placenta Internal medicine Mole Biomarkers Tumor medicine Humans Chorionic Gonadotropin beta Subunit Human Inhibins Longitudinal Studies reproductive and urinary physiology Retrospective Studies Gestational age Hydatidiform Mole medicine.disease Peptide Fragments female genital diseases and pregnancy complications medicine.anatomical_structure Uterine Neoplasms embryonic structures biology.protein Female Gonadotropin hormones hormone substitutes and hormone antagonists ATP synthase alpha/beta subunits |
| Zdroj: | Clinical Endocrinology. 41:155-162 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1994.tb02524.x |
| Popis: | Summary OBJECTIVE The purpose of the study was to evaluate plasma inhibin as a marker of hydatidiform mole and to compare the results with intact human chorionic gonadotrophin (hCG) and its free β-subunit. DESIGN Serial determinations of the plasma concentrations of inhibin, intact human chorionic gonadotrophin and its free β-subunit in cases of hydatidiform mole over an average period of 140 days. PATIENTS Five cases of hydatidiform mole, including patients with spontaneous remission after evacuation or persistent trophoblastic disease. MEASUREMENTS Immunoreactive Inhibin, hCG and free hCG β-subunit were measured using standard enzyme immunoassays. RESULTS inhibin and free hCG β-subunit levels were greater than in normal pregnant women at the same gestational age. Only intact hCG could detect the persistence of trophoblastic tissue. CONCLUSIONS Our data suggest that inhibin, intact human chorionic gonadotrophin and free β-subunit might be useful as diagnostic markers of molar pregnancies. However, the original method of intact hCG determination Is still superior for follow-up. |
| Databáze: | OpenAIRE |
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