Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain

Autor: Philippe Lestaevel, Cyrill Bussy, C. Amourette, B. Dhieux, François Paquet, P. Houpert, Patrick Gourmelon
Přispěvatelé: Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), centre de recherches du Service de Santé des Armées, Centre de Recherches du Service de Santé des Armées
Rok vydání: 2005
Předmět:
cognition
Male
hippocampus
correlation analysis
[SDV]Life Sciences [q-bio]
Dopamine
Hippocampus
Striatum
Toxicology
Weight Gain
Rats
Sprague-Dawley
chemistry.chemical_compound
Eating
0302 clinical medicine
monoamine
rat
dopaminergic activity
Neurotransmitter
Chromatography
High Pressure Liquid
0303 health sciences
Chromatography
frontal cortex
General Neuroscience
Dopaminergic
article
drug brain level
Hydroxyindoleacetic Acid
Acetylcholinesterase
enzyme activity
priority journal
High Pressure Liquid
Uranyl Nitrate
Uranium
medicine.drug
neurotransmitter
medicine.medical_specialty
Serotonin
animal experiment
neurochemistry
Drinking
long term exposure
03 medical and health sciences
Neurochemical
4-Dihydroxyphenylacetic Acid
Internal medicine
medicine
Animalia
Animals
controlled study
Biogenic Monoamines
4 dihydroxyphenylacetic acid
corpus striatum
030304 developmental biology
Brain Chemistry
nonhuman
behavior
serotoninergic system
Rats
Endocrinology
dopaminergic system
chemistry
Cholinergic
3
4-Dihydroxyphenylacetic Acid
Sprague-Dawley
Cholinesterase Inhibitors
030217 neurology & neurosurgery
Zdroj: Neurotoxicology
Neurotoxicology, 2006, 27 (2), pp.245-252. ⟨10.1016/j.neuro.2005.11.003⟩
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2005.11.003⟩
Popis: Recent animal studies have shown that uranium can reach the brain after chronic exposure. However, little information is available on the neurological effects of chronic long-term exposure to uranium. In the present study, the effects during 1.5, 6 and 9-month periods of chronic ingestion of uranyl nitrate (UN) in drinking water (40 mg of uranium per litre) on cholinergic acetylcholinesterase (AChE) activity and on dopaminergic and serotoninergic metabolisms were investigated in several areas of male Srague Dawley rat brains. Uranium brain accumulation and distribution was also investigated after 1.5 and 9 months. Both after 1.5, 6 and 9 months of exposure, AChE activity was unaffected in the striatum, hippocampus and frontal cortex. Nevertheless, AChE activity was transitionally perturbed in the cerebellum after 6 months of exposure. After 1.5 months of exposure, DA level increased in hypothalamus. After 6 months of exposure, a tiny but significant modification of the DAergic turnover ratio was detected in the frontal cortex. And after 9 months, UN produced a significant decrease in the 5HIAA level and the 5HTergic turn-over ratio in the frontal cortex and also a decrease in the DOPAC level and DAergic turn-over ratio in the striatum. Uranium brain accumulation was statistically significant in striatum after 1.5 months and in striatum, hippocampus and frontal cortex after 9 months of exposure. Although neurochemical changes did not always correlated with increased accumulation of uranium in specific areas, these results suggest that chronic ingestion of UN can cause chronic and progressive perturbations of physiological level of neurotransmitter systems. Considering previous reports on behavioural uranium-induced effects and the involvement of neurotransmitters in various behavioural processes, it would be crucial to determine whether these neurochemical disorders were accompanied by neurobehavioral deficits even at 40 mg of uranium per litre exposure. © 2005 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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