Th17-Related Cytokines in Inflammatory Bowel Diseases: Friends or Foes?
| Autor: | I. Monteleone, Massimiliano Sarra, Giovanni Monteleone, Francesco Pallone |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Inflammation
Disease Models Biological Biochemistry Interleukin 20 In vivo Interleukin 25 medicine Animals Humans Molecular Biology Settore MED/12 - Gastroenterologia business.industry Interleukin-17 Interleukin T-Lymphocytes Helper-Inducer General Medicine Colitis Inflammatory Bowel Diseases medicine.disease Ulcerative colitis In vitro Immunology Molecular Medicine medicine.symptom business |
| Zdroj: | Current Molecular Medicine. 12:592-597 |
| ISSN: | 1566-5240 |
| DOI: | 10.2174/156652412800620066 |
| Popis: | T helper (Th)17 cells and other interleukin (IL)-17-producing cells are supposed to play critical roles in several human immune-mediated diseases, including Crohn's disease (CD) and ulcerative colitis (UC), the main forms of inflammatory bowel diseases (IBD) in man. Th17 cells infiltrate massively the inflamed intestine of IBD patients and in vitro and in vivo studies have shown that Th17-type cytokines may trigger and amplify multiple inflammatory pathways. Nonetheless, some Th17-related cytokines, such as interleukin (IL)-17A and IL-22, may target gut epithelial cells and promote the activation of counter-regulatory mechanisms. This observation together with the demonstration that Th17 cells are not stable and can be converted into either regulatory T cells or Th1 cells if stimulated by immune-suppressive (e.g. TGF-β1) or inflammatory (e.g. IL-12, IL-23) cytokines have contributed to advance our understanding of mechanisms that regulate mucosal homeostasis and inflammation in the gut. |
| Databáze: | OpenAIRE |
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