Influence of Thyroid Status on Hemoglobin A2Expression
| Autor: | Jean-Pierre Luton, Bricaire H, Jean-Marc Kuhn, Max Rieu, Rajagopal Krishnamoorthy, Jacques Elion, Jacques Rochette, Dominique Labie |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Erythrocyte Indices Male Thyroid Hormones medicine.medical_specialty Iron Endocrinology Diabetes and Metabolism medicine.medical_treatment Thalassemia Clinical Biochemistry Hyperthyroidism Biochemistry Endocrinology Hypothyroidism Hemoglobin A2 Internal medicine medicine Humans Euthyroid Red blood cell indices Fetal Hemoglobin Aged medicine.diagnostic_test Chemistry Antithyroid agent Biochemistry (medical) Thyroid Hemoglobin A Middle Aged medicine.disease medicine.anatomical_structure Erythrocyte Count Female Hemoglobin |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 57:344-348 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-57-2-344 |
| Popis: | We studied the electrophoretic pattern of hemoglobin (Hb) and red blood cell indices in 128 women divided into four groups: group I, 36 nonanemic hyperthyroid women, divided in two subgroups: 36 with untreated hyperthyroidism (subgroup IA) and 9 made euthyroid by antithyroid drug therapy (subgroup IB); group II, 12 nonanemic women with untreated hypothyroidism; group III, 30 women known to be heterozygous for beta-thalassemia; and group IV, 50 healthy women. The mean (+/- SEM) HbA2 level was higher (P less than 0.001) in subgroup IA (3.21 +/- 0.06%) than in subgroup IB (2.42 +/- 0.09%) and group IV (2.48 +/- 0.04%), but lower (P less than 0.001) than in group III (5.26 +/- 0.12%). The mean HbA2 level was lower (P less than 0.001) in group II (1.99 +/- 0.08%) than in group IV. Hb fetal was detectable in eight patients of subgroup IA and undetectable in subgroup IB and groups II and IV. The mean cellular volume was lower (P less than 0.001) in subgroup IA than in other nonanemic groups. The mean cellular volume was higher (P less than 0.001) in group II than in group IV. Follow-up of nine patients who became euthyroid with treatment showed the normalization of these erythrocyte parameters. These results suggest that thyroid hormones can modulate the synthesis of delta- and gamma-globin chains. |
| Databáze: | OpenAIRE |
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