Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: a pooled analysis of seven European birth cohort studies
| Autor: | Hein Stigum, Jürgen Wittsiepe, Matias Torrent, Gunnar Toft, Isabelle Sioen, Joan Forns, Jesús Ibarluzea, Martine Vrijheid, Tomas Trnovec, Eva Govarts, Birgit Bjerre Høyer, Merete Eggesbø, Maria-Jose Lopez-Espinosa, Eva Sovcikova, Nina Iszatt, Mònica Guxens, Nikola Nowack, Cécile Chevrier |
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| Přispěvatelé: | Norwegian Institute of Public Health [Oslo] (NIPH), Bispebjerg University Hospital, Aarhus University Hospital, Universiteit Gent = Ghent University [Belgium] (UGENT), Slovak Medical University of Bratislava (SMU), Ruhr University Bochum (RUB), Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) of Pamplona, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Erasmus University Medical Centre Rotterdam/Sophia Children's Hospital, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Unit Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Norges Forskningsråd, ANR-2010-PRSP-007, Agence Nationale de la Recherche, APVT-21–016804, Agentúra na Podporu Výskumu a Vývoja, FP7/2007–2013, European Community’s Seventh Framework, Norwegian Data Inspectorate, 282957, DENAMIC, 226402, NEVRINOR, S-02122, Regional Ethics Committee for Medical Research in Norway, EU, European Union, FP7-ENV-2011 cod 282957, NEWGENERIS, MS13/00054, Miguel Servet-FEDER, DFG06/004, Provincial Government of Gipuzkoa, 1999SGR 00241, Generalitat de Catalunya-CIRIT, 090430, La Fundació La Marató de TV3, 2009111069, Conselleria de Sanitat Generalitat Valenciana, Department of Health of the Basque Government, Obra Social Cajastur, PI17/00663, Instituto de Salud Carlos III, 183/07, Consejería de Salud de la Junta de Andalucía, QLK4–2002-00603, EU Commission, QLK4-CT-2001–00202, European Commission’s 7th and 5th Framework Programmes, Universidad de Oviedo, R01 CA096525, National Institutes of Health, ANR-10-PRSP-0007,PEPSY(2010), Jonchère, Laurent, PROGRAMME DE RECHERCHE EN SANTE PUBLIQUE - - PEPSY2010 - ANR-10-PRSP-0007 - PRSP - VALID, Universiteit Gent = Ghent University (UGENT), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Child and Adolescent Psychiatry / Psychology |
| Rok vydání: | 2018 |
| Předmět: |
Male
Epidemiology 010501 environmental sciences 01 natural sciences Cohort Studies 0302 clinical medicine Pregnancy Hexachlorobenzene Child education.field_of_study Perinatal Exposure General Medicine Environmental exposure Fetal Blood Polychlorinated Biphenyls 3. Good health Europe Maternal Exposure Child Preschool Prenatal Exposure Delayed Effects Environmental Pollutants Female Cohort study Adolescent polychlorinated biphenyls Dichlorodiphenyl Dichloroethylene Population Prenatal care attention-deficit disorder with hyperactivity DDT 03 medical and health sciences medicine Attention deficit hyperactivity disorder Humans education Prenatal Exposures to Pollutants 0105 earth and related environmental sciences business.industry Odds ratio Environmental Exposure medicine.disease Logistic Models hexachlorobenzene [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Attention Deficit Disorder with Hyperactivity [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business 030217 neurology & neurosurgery Demography |
| Zdroj: | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) International Journal of Epidemiology International Journal of Epidemiology, Oxford University Press (OUP), 2018, 47 (4), pp.1082-1097. ⟨10.1093/ije/dyy052⟩ Forns, J, Stigum, H, Høyer, B B, Sioen, I, Sovcikova, E, Nowack, N, Lopez-Espinosa, M-J, Guxens, M, Ibarluzea, J, Torrent, M, Wittsiepe, J, Govarts, E, Trnovec, T, Chevrier, C, Toft, G, Vrijheid, M, Iszatt, N & Eggesbø, M 2018, ' Prenatal and postnatal exposure to persistent organic pollutants (POPs) and attention-deficit and hyperactivity disorder (ADHD): a pooled analysis of seven European birth cohort studies ', International Journal of Epidemiology, pp. 1082-1097 . https://doi.org/10.1093/ije/dyy052 International Journal of Epidemiology, 2018, 47 (4), pp.1082-1097. ⟨10.1093/ije/dyy052⟩ r-FISABIO. Repositorio Institucional de Producción Científica instname International Journal of Epidemiology, 47(4), 1082-1097. Oxford University Press |
| ISSN: | 0300-5771 1464-3685 |
| DOI: | 10.1093/ije/dyy052⟩ |
| Popis: | International audience; Background - Attention-deficit/hyperactivity disorder (ADHD) is increasing worldwide for reasons largely unknown and environmental chemicals with neurotoxic properties, such as persistent organic pollutants (POPs), have been proposed to play a role. We investigated the association between prenatal and postnatal exposure to polychlorinated biphenyl-153 (PCB-153), p-p´-dichlorodiphenyldichloroethylene (p-p'-DDE) and hexachlorobenzene (HCB) and ADHD in childhood. Methods - We pooled seven European birth cohort studies encompassing 4437 mother-child pairs from the general population with concentrations of PCB-153, p-p´-DDE and HCB measured in cord blood, maternal blood or milk. We then calculated prenatal (birth) and postnatal (3, 6, 12 and 24 months) POP concentrations using a pharmacokinetic model. The operational definition of ADHD varied across cohorts and ranged from doctor diagnosis obtained from patient registries to maternal or teachers reports. We used multilevel (mixed) logistic regression models to estimate the associations between exposure to POPs at birth, 3, 6, 12 and 24 months and ADHD. Results - The global prevalence of ADHD in our study was 6%. The mean age at assessment of ADHD was 5.8 years (range: 3.8-9.5 years). We found no association between exposure to PCB-153, p-p´-DDE and HCB at any age point between birth and 24 months and ADHD, in the pooled analyses (pooled odds ratios ranging from 1.00 to 1.01). A number of sensitivity analyses gave basically the same results. Conclusions - In the largest study to date of 4437 children in seven European birth cohorts, we did not observe any association between either pre- or postnatal exposure (up to 24 months) to PCB-153, p-p´-DDE and HCB and the risk of ADHD before the age of 10 years. |
| Databáze: | OpenAIRE |
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