Tumor treating fields: a novel treatment modality and its use in brain tumors
| Autor: | Roger Stupp, Patricia Pacheco, Andreas F. Hottinger |
|---|---|
| Přispěvatelé: | University of Zurich, Hottinger, Andreas F |
| Rok vydání: | 2016 |
| Předmět: |
Organelle assembly
Oncology Cancer Research medicine.medical_specialty Pathology medicine.medical_treatment Electric Stimulation Therapy 610 Medicine & health 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Humans 1306 Cancer Research Progression-free survival Chemotherapy Invited Review Temozolomide Brain Neoplasms business.industry Cancer Brain Neoplasms/therapy Electric Stimulation Therapy/methods Electric Stimulation Therapy/trends Glioblastoma/therapy medicine.disease Chemotherapy regimen 2728 Neurology (clinical) medicine.anatomical_structure Treatment modality 030220 oncology & carcinogenesis Scalp 10032 Clinic for Oncology and Hematology 2730 Oncology Neurology (clinical) Glioblastoma business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuro-oncology, vol. 18, no. 10, pp. 1338-1349 Neuro-Oncology |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/now182 |
| Popis: | Tumor treating fields (TTFields) are low-intensity electric fields alternating at an intermediate frequency (200kHz), which have been demonstrated to block cell division and interfere with organelle assembly. This novel treatment modality has shown promise in a variety of tumor types. It has been evaluated in randomized phase 3 trials in glioblastoma (GBM) and demonstrated to prolong progression-free survival (PFS) and overall survival (OS) when administered together with standard maintenance temozolomide (TMZ) chemotherapy in patients with newly diagnosed GBM. TTFields are continuously delivered by 4 transducer arrays consisting each of 9 insulated electrodes that are placed on the patient’s shaved scalp and connected to a portable device. Here we summarize the preclinical data and mechanism of action, the available clinical data, and further outlook of this treatment modality in brain tumors and other cancer indications. |
| Databáze: | OpenAIRE |
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