Supplementary Figures S1-7 from Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy

Autor: Leonie S. Young, Arnold D. Hill, Peadar Ó Gaora, Paul Tibbitts, Lance Hudson, Marie McIlroy, Jarlath Bolger, Christopher Byrne, Sinéad Cocchiglia, Damir Varešlija, Fiona T. Bane, Damian McCartan, Ailís Fagan, Jean McBryan
Rok vydání: 2023
Popis: Supplementary Figures S1-7. Supplementary Figure S1: Gene expression profiles of classic biomarkers in matched tumour samples from 3 patients. Supplementary Figure S2: Network map showing the enriched KEGG pathways from upregulated differentially expressed genes (DEGs). Supplementary Figure S3: Network map showing the enriched KEGG pathways from downregulated differentially expressed genes (DEGs). Supplementary Figure S4: Protein expression in matched primary and metastatic tissue from endocrine treated breast cancer patients. Supplementary Figure S5: Phosphorylated mTOR signaling in endocrine resistant breast cancer tumours. Supplementary Figure S6: Interaction plot showing functional roles for 21 genes commonly upregulated in metastatic liver tumours of all three patients. Supplementary Figure S7: Genes upregulated in liver metastases are also strongly expressed in breast metastases to the brain.
Databáze: OpenAIRE