Malignant transformation to oral cancer by subtype of oral potentially malignant disorder: A prospective cohort study of Taiwanese nationwide oral cancer screening program
| Autor: | Mu Kuan Chen, William Wang Yu Su, Chiu Wen Su, Shu Lin Chuang, Jean Ching Yuan Fann, Sam Li Sheng Chen, Cheng-Ping Wang, Sherry Yueh Hsia Chiu, Amy Ming Fang Yen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Cancer Research Gastroenterology Malignant transformation 0302 clinical medicine Risk Factors Medicine Prospective Studies Early Detection of Cancer Leukoplakia Aged 80 and over Erythroplakia education.field_of_study biology Incidence Middle Aged Betel Cell Transformation Neoplastic Oncology 030220 oncology & carcinogenesis Female Mouth Neoplasms Leukoplakia Oral Oral Surgery Adult medicine.medical_specialty Adolescent Alcohol Drinking Population Taiwan Young Adult 03 medical and health sciences Internal medicine Humans education Areca Mass screening Aged Hyperplasia business.industry Mouth Mucosa Cancer 030206 dentistry medicine.disease biology.organism_classification stomatognathic diseases Oral submucous fibrosis business Precancerous Conditions Follow-Up Studies |
| Zdroj: | Oral Oncology. 87:58-63 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/j.oraloncology.2018.10.021 |
| Popis: | Objectives To elucidate the risk of malignant transformation to invasive oral cancer by subtypes of oral potentially malignant disorders (OPMD) and to examine the independent effects of risk factors, particularly alcohol drinking, by subtype based on a nationwide oral cancer screening program targeting at general population with habits of smoking and/or betel quids chewing. Materials and methods The total of 8501 subjects diagnosed as different subtypes of OPMDs from the Taiwanese screening program between 2004 and 2009 were followed up over time to ascertain the occurrence of invasive oral cancer. The hazard ratios of malignant transformation were estimated by using Cox proportional hazards regression model. Results The overall malignant rate (per 1000 person-years) to oral cancer was 8.4 (407 incident cases with an average of 5.7 years of follow-up). The highest rate was noted in exophytic verrucous hyperplasia (33), followed by erythroplakia (11.8), erythroleukoplakia (10.7), oral submucous fibrosis (OSF) (8.6), and leukoplakia (5.4). After adjusting for confounders, exophytic verrucous hyperplasia still had a 5.69 (4.47–7.24) times risk compared with leukoplakia. The corresponding figures for erythroplakia, erythroleukoplakia, and OSF were 2.25 (1.31–3.89), 2.00 (1.13–3.53), and 1.63 (1.29–2.06), respectively. Alcohol drinking elevated the overall risk of malignant transformation by 23% (1–52% and also triggered a higher risk in OSF (aHR = 1.62 (1.06–2.47)). The higher risk attributed to betel quids chewing was noted for exophytic verrucous hyperplasia (aHR = 4.23 (1.55–11.55)). Conclusions The risk of malignant transformation to oral cancer varied with the subtypes of OPMD and was elevated in OSF and verrucous hyperplasia attributed to alcohol drinking and betel quids, respectively. |
| Databáze: | OpenAIRE |
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