Cefamandole: In Vitro and Clinical Pharmacokinetics
| Autor: | Gordon Brier, J. D. Wolny, H. R. Black, R. S. Griffith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Time Factors medicine.drug_class Cephalosporin Antibiotics Microbial Sensitivity Tests Biology Pharmacology medicine.disease_cause Injections Intramuscular Microbiology Haemophilus influenzae Minimum inhibitory concentration medicine Potency Humans Pharmacology (medical) Infusions Parenteral Cefamandole Enterobacter Middle Aged biology.organism_classification Pharmacology and Therapeutics Cephalosporins Penicillin Kinetics Infectious Diseases Mandelic Acids Female medicine.drug Protein Binding |
| Popis: | Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae , most strains of Enterobacter , and many strains of indole-positive Proteus and Bacteroides , with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella , etc. Concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. Approximately 65 to 85% is excreted in a biologically active form in the urine. This antibiotic offers advantages of antibacterial effectiveness and at the same time retains the safety of penicillin G and cephalothin in animals. |
| Databáze: | OpenAIRE |
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