In vitro and in vivo study of dye diffusion into the human skin and hair follicles
| Autor: | Yurii P. Sinichkin, Valery V. Tuchin, Nina A. Lakodina, Alexey N. Bashkatov, Gregory B. Altshuler, Vyacheslav I. Kochubey, Elina A. Genina |
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| Rok vydání: | 2001 |
| Předmět: |
Sebaceous gland
Pathology medicine.medical_specialty Biomedical Engineering Human skin Absorption (skin) In Vitro Techniques Hair Removal Skin Diseases Biomaterials Diffusion chemistry.chemical_compound In vivo medicine Humans Penetration depth Coloring Agents Skin integumentary system Chemistry Hair follicle Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials medicine.anatomical_structure Spectrophotometry Biophysics Laser Therapy Dyeing Indocyanine green Hair Follicle |
| Zdroj: | Journal of biomedical optics. 7(3) |
| ISSN: | 1083-3668 |
| Popis: | We present experimental results on the in vitro and in vivo study of dye diffusion into human skin and hair follicles. We have studied some commercially available dyes for potential using in the laser selective thermolysis. The degree and the depth of hair follicle dyeing inside the skin were determined. For hairs in different stages the sebaceous gland was stated as a reservoir for a dye administration. It was found that the penetration depth of dyes is about 1.2 mm from the skin surface. We have developed the biocompatible Indocyanine Green lotions and the method for in vivo dyeing and dye in depth monitoring. Shift on 16-21 nm of absorption peak of Indocyanine Green to the longer wavelengths due to Indocyanine Green binding with cell proteins in the human skin was found. |
| Databáze: | OpenAIRE |
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