Epstein-Barr virus-encoded LMP1 triggers regulation of the ERK-mediated Op18/stathmin signaling pathway in association with cell cycle
| Autor: | Min Tang, Lili Li, Zijian Li, Xuechi Lin, Juan Xu, Xiaoqian Ma, Ya Cao, Sufang Liu, Lili Guo, Yongguang Tao |
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| Rok vydání: | 2011 |
| Předmět: |
MAPK/ERK pathway
Cancer Research Herpesvirus 4 Human MAP Kinase Signaling System Cell Stathmin Receptors Cell Surface macromolecular substances Microtubules Viral Matrix Proteins Cell Line Tumor medicine Humans RNA Small Interfering Extracellular Signal-Regulated MAP Kinases Nasopharyngeal Carcinoma biology Cell growth Chemistry Carcinoma Cell Cycle Nasopharyngeal Neoplasms General Medicine DNA Catalytic Oncogene Proteins Viral Original Articles Cell cycle Cell biology medicine.anatomical_structure Oncology biology.protein Phosphorylation RNA Interference Signal transduction Intracellular |
| Zdroj: | Cancer Sci |
| ISSN: | 1349-7006 |
| Popis: | The MAPKs are activated by a variety of cellular stimuli to participate in a series of signaling cascades and mediate diverse intracellular responses. One potential target of the MAPKs is Op18/stathmin, a molecule that acts as an integrator of diverse cell signaling pathways and regulates the dynamics of microtubules, which are involved in modulating a variety of cellular processes, including cell cycle progression and cell growth. Our study focused on the regulation of the MAPK‐mediated Op18/stathmin signaling pathway, which is triggered by the Epstein–Barr virus‐encoded latent membrane protein 1 (LMP1) oncogene in nasopharyngeal carcinoma cells. The results showed that the activity of MAPK, which was induced by LMP1, varied with cell cycle progression; LMP1 upregulated phosphorylation of ERK during the G(1)/S phase, but negatively regulated phosphorylation of ERK during the G(2)/M phase. We found that the regulation of Op18/stathmin signaling by LMP1 was mainly mediated through ERK. The inhibition of LMP1 expression attenuated the interaction of ERK with Op18/stathmin and promoted microtubule depolymerization. These findings indicate the existence of a new cell cycle‐associated signaling pathway in which LMP1 regulates ERK‐mediated Op18/stathmin signaling. (Cancer Sci 2012; 103: 993–999) |
| Databáze: | OpenAIRE |
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