α-zingiberene, a sesquiterpene from essential oil from leaves of Casearia sylvestris, suppresses inflammatory angiogenesis and stimulates collagen deposition in subcutaneous implants in mice
| Autor: | Bruno Antonio Ferreira, Ricardo Ferreira Silva, Francyelle Borges Rosa de Moura, Carolina Tannús Narduchi, Simone Ramos Deconte, Patricia Sartorelli, Tatiana Carla Tomiosso, João Henrique Ghilardi Lago, Fernanda de Assis Araújo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Natural Product Research. 36:5858-5862 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2021.2019729 |
| Popis: | α-zingiberene is a phytochemical of the sesquiterpenes class, the major constituent of the essential oil from the leaves of Casearia sylvestris, a plant widely used in traditional medicine for the treatment of inflammatory diseases, tumours, and bacterial infections. In the present study, we evaluated the effects of daily administration of α-zingiberene (0.01, 0.1 and 1 μg diluted in 10 μl of 0.5% DMSO) on the inflammatory, angiogenic, and fibrogenic components, induced by subcutaneous sponge implants in an animal model. Treatment with sesquiterpene resulted in a reduction in macrophage activation, as well as in mean blood vessels and in the activity of metalloproteinases 2 and 9. Furthermore, it resulted in an increase in collagen deposition near the implants. These results show the therapeutic potential of α-zingiberene in the treatment of pathologies, in which processes such as inflammation and angiogenesis are exacerbated, or even for the treatment of chronic wounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|