Myricitrin degraded by simulated digestion inhibits oxidation of human low-density lipoprotein
| Autor: | Atsushi Yokomizo, Masamitsu Moriwaki |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Apolipoprotein B
Flavonoid alpha-Tocopherol Amidines Applied Microbiology and Biotechnology Biochemistry Antioxidants Analytical Chemistry chemistry.chemical_compound Phenethylamines Humans Lipoprotein oxidation Molecular Biology Chromatography High Pressure Liquid Edetic Acid Apolipoproteins B Chelating Agents chemistry.chemical_classification Flavonoids biology Molecular Structure Cholesterol Spectrum Analysis Organic Chemistry General Medicine Hydrogen-Ion Concentration Gastrointestinal Tract Lipoproteins LDL chemistry Low-density lipoprotein Apolipoprotein B-100 biology.protein lipids (amino acids peptides and proteins) Digestion Myricitrin Oxidation-Reduction Copper Biotechnology Lipoprotein |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 69(4) |
| ISSN: | 0916-8451 |
| Popis: | The inhibitory effects of myricitrin on the oxidation of human low-density lipoprotein were investigated before and after its degradation by simulated digestion. Myricitrin strongly inhibited the low-density lipoprotein oxidation induced by either 2,2'-azobis (2-amidinopropane) dihydrochloride or CuSO4 in a concentration-dependent manner. Myricitrin was very stable under an acidic condition (pH 1.8) corresponding to the gastric environment, but it was easily degraded under an alkaline condition (pH 8.5) corresponding to the intestinal environment. However, degraded myricitrin also had a strong inhibitory effect on the oxidative degradation of alpha-tocopherol, cholesterol and apolipoprotein B-100 in low-density lipoprotein. Our study revealed that myricitrin was degraded into many components under a mildly alkaline condition, but the degraded myricitrin still retained the free radical-scavenging and copper-chelating activities toward low-density lipoprotein. |
| Databáze: | OpenAIRE |
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