Surgical Patterns of Care in Operable Lung Carcinoma Treated with Radiation
| Autor: | Corey J. Langer, Ritsuko Komaki, Melvyn Goldberg, David W. Johnstone, Jean B. Owen, Jennifer Moughan, Benjamin Movsas, Joe Y. Chang, Beth M. Beadle |
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| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Radiotherapy business.industry medicine.medical_treatment Retrospective cohort study medicine.disease Surgery Radiation therapy Bilobectomy Pneumonectomy Oncology Carcinoma medicine Chemotherapy Pattern of care Lung cancer business Neoadjuvant therapy Wedge resection (lung) |
| Zdroj: | Journal of Thoracic Oncology. 1:526-531 |
| ISSN: | 1556-0864 |
| DOI: | 10.1016/s1556-0864(15)30354-3 |
| Popis: | Purpose To determine the national surgical practice patterns of care for operable lung cancer patients treated with radiation. Materials and Methods A nationwide survey of a stratified random sample of institutions was conducted for patients who had non-metastatic lung cancer, Karnofsky Performance Scores (KPS) ≥60, and who had received radiation therapy as definitive or adjuvant treatment. Among 541 patients, representing a weighted sample size of 42,335 patients nationwide, 131 (19.8%) underwent surgery as part of their therapy. Pearson χ 2 statistics were used to analyze characteristics of this subset of patients. Results Of the 131 patients who underwent surgery, 126 patients who had non-small cell lung cancer (NSCLC) were analyzed. Surgical patients were younger, had less weight loss, higher KPS, and higher forced expiratory volume within 1 second (FEV1) values than those treated without surgery. Surgical patients had more stage I/II (53.5% vs 32.2%; p = 0.0004) and less clinical N2/N3 disease (28.8% vs 47.5%; p = 0.002) than nonsurgical patients. Surgery consisted of lobectomy or bilobectomy in 63.2% of patients, pneumonectomy in 23.5%, and wedge resection in 5.9%. Of the patients, 80.4% received radiation in the adjuvant setting and 9.9% in the neoadjuvant setting. Conclusions Patients with non-metastatic lung cancer who are treated surgically and with radiation have clinically less advanced disease than those treated with radiation alone. Most radiation therapy in this setting is administrated postoperatively and secondary to hilar and/or mediastinal nodal involvement undetected before surgery. Improved preoperative nodal staging and neoadjuvant approaches may alter these practice patterns. |
| Databáze: | OpenAIRE |
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