Regulatory T cells control uveoretinitis induced by pathogenic Th1 cells reacting to a specific retinal neoantigen
| Autor: | David Klatzmann, Phuc LeHoang, Sylvain Fisson, Benoît L. Salomon, Bahram Bodaghi, Mohammed Kaddouri, Yvonne de Kozak, Céline Terrada |
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| Rok vydání: | 2006 |
| Předmět: |
Immunology
Genetic Vectors Receptors Antigen T-Cell Epitopes T-Lymphocyte Hemagglutinin Glycoproteins Influenza Virus Mice Transgenic Biology T-Lymphocytes Regulatory Epitope Retina Proinflammatory cytokine Uveitis Interleukin 21 Mice Antigen Cell Movement medicine Immunology and Allergy Cytotoxic T cell Animals IL-2 receptor Antigens Viral Mice Inbred BALB C Retinitis Dependovirus Th1 Cells medicine.disease Vitreous Body medicine.anatomical_structure Radiation Chimera Cytokines Female |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 176(12) |
| ISSN: | 0022-1767 |
| Popis: | In many clinical cases, uveitis develops secondary to an infection. This could result from peripheral activation followed by ocular penetration and reactivation of T cells specific for microbial Ags expressed in the retina. To gain insights into the pathophysiology of uveitis, we developed a new mouse model based on stable retinal expression of influenza virus hemagglutinin (HA) neoantigen by adeno-associated virus-mediated gene transfer. One month thereafter, we adoptively transferred HA-specific T cells, which were activated in vitro or in vivo. Intraocular inflammation was clinically and histologically observed in all animals within 15 days. The ocular infiltrate was composed mostly of macrophages and HA-specific T cells with a proinflammatory cytokine profile. Depletion of CD4+CD25+ regulatory T cells exacerbated the disease, whereas HA-specific CD4+CD25+ T cells given i.v. controlled the disease. This novel model should allow to better study the pathophysiology and therapeutic of uveitis. |
| Databáze: | OpenAIRE |
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