Dose-dependent effects of peptide YY(3-36) on conditioned taste aversion in rats
| Autor: | Prasanth K. Chelikani, Roger D. Reidelberger, Alvin C. Haver |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Taste Physiology Biochemistry Malaise Peptide YY-3 Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine medicine Avoidance Learning Animals Peptide YY Food science Infusions Intravenous Saccharin Gastric emptying Dose-Response Relationship Drug digestive oral and skin physiology Peptide Fragments Rats Dose–response relationship chemistry Taste aversion Conditioning Conditioning Operant medicine.symptom hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 27(12) |
| ISSN: | 0196-9781 |
| Popis: | We used a conditioned taste aversion test to assess whether PYY(3-36) reduces food intake by producing malaise. Two-hour IV infusion of PYY(3-36) (8, 15, and 30 pmol/kg/min) at dark onset in non-food-deprived rats produced a dose-dependent inhibition of feeding and a conditioned aversion to the flavored chow paired with PYY(3-36) infusion. In food-deprived rats, PYY(3-36) at 2 and 4 pmol/kg/min inhibited intake of a flavored saccharin solution without producing conditioned taste aversion, whereas higher doses (8 and 15 pmol/kg/min) inhibited saccharin intake and produced taste aversion. These results suggest that anorexic doses of PYY(3-36) may produce a dose-dependent malaise in rats, which is similar to that reported for PYY(3-36) infusion in humans. Previous studies have shown that PYY(3-36) potently inhibits gastric emptying, and that gut distention can produce a conditioned taste aversion. Thus, PYY(3-36) may produce conditioned taste aversion in part by slowing gastric emptying. |
| Databáze: | OpenAIRE |
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