Vascular inflammation and impaired reverse cholesterol transport and lipid metabolism in obese children and adolescents
| Autor: | Patricia Palenque, Laura Boero, Eliana Botta E, Maria Victoria LorenzonGonzalez, Ezequiel Lozano Chiappe, Maximiliano Martin, María Soledad Saez, Fernando Brites, Viviana Osta, Patricia Sorroche, Gabriela Ballerini, Liliana Triffone, Laura Gaete, Walter Francisco Tetzlaff, Florencia Ferraro |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pediatric Obesity Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) chemistry.chemical_compound Insulin resistance Internal medicine Cholesterylester transfer protein medicine Humans Child Triglycerides Inflammation Nutrition and Dietetics medicine.diagnostic_test biology Cholesterol business.industry Reverse cholesterol transport Cholesterol HDL Lipid metabolism medicine.disease Lipid Metabolism Endocrinology chemistry biology.protein lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Lipid profile business Dyslipidemia Lipoprotein |
| Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD. 32(1) |
| ISSN: | 1590-3729 |
| Popis: | Background and Aims Childhood obesity is associated to complications such as insulin resistance and dyslipidemia. High density lipoproteins (HDL) constitute the only lipoprotein fraction with ateroprotective properties. The aim of the present study was to analyze inflammatory markers, carbohydrate metabolism, lipid profile and HDL functionality in obese children and adolescents compared to healthy controls. Methods and Results Twenty obese children and adolescents (Body mass index z score >3.0) (9-15 years old) and 20 age and sex similar controls were included in the study. Triglyceride (TG), total cholesterol (TC), HDL-C, LDL-C, apolipoproteins (apo) A-I and B, glucose and insulin levels were quantified. Lipid indexes and HOMA-IR were calculated. Cholesterol efflux (CEC), lipoprotein associated phospholipase A2 (Lp-PLA2), lecithin-cholesterol acyl transferase (LCAT) and cholesteryl ester transfer protein, plus paraoxonase and arylesterase (ARE) activities were evaluated. Obese children and adolescents showed significantly higher TG [69 (45-95) vs 96 (76-121); p Conclusion The obese group showed alterations in carbohydrate and lipid metabolism, which were associated to the presence of vascular specific inflammation and impairment of HDL atheroprotective capacity. These children and adolescents would present qualitative alterations in their lipoproteins which would determine higher risk of suffering premature cardiovascular disease. |
| Databáze: | OpenAIRE |
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