Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study
Autor: | Sara Raimondi, Francesca De Piano, Giuseppe Petralia, Caterina Giannitto, Pier Francesco Ferrucci, Marta Minotti, Giorgio Conte, Lorenzo Preda, Emilia Cocorocchio, Massimo Bellomi |
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Rok vydání: | 2017 |
Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Gadolinium chemistry.chemical_element Contrast Media Globus Pallidus 030218 nuclear medicine & medical imaging Gadoxetate Disodium 03 medical and health sciences 0302 clinical medicine Thalamus Pons T1 weighted Medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies medicine.diagnostic_test business.industry Ultrasound Magnetic resonance imaging General Medicine Middle Aged Magnetic Resonance Imaging Dentate nucleus Globus pallidus chemistry Cerebellar Nuclei Anesthesia Female Radiology Signal intensity business Nuclear medicine 030217 neurology & neurosurgery |
Zdroj: | European radiology. 27(10) |
ISSN: | 1432-1084 |
Popis: | To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations. Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively). Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain. • Gadolinium may deposit in the human brain after multiple GBCA administrations. • Gadolinium deposition is associated with increased T1W signal intensity • Increase in signal intensity is most apparent within the DN and GP • Multiple administrations of gadoxetate disodium do not increase T1W signal |
Databáze: | OpenAIRE |
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