The blood lipid regulation of Monascus-produced monascin and ankaflavin via the suppression of low-density lipoprotein cholesterol assembly and stimulation of apolipoprotein A1 expression in the liver
| Autor: | Ja-Yan Wen, Ya-Wen Hsu, Chun-Lin Lee, Tzu-Ming Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine Apolipoprotein B lcsh:QR1-502 Blood lipids 01 natural sciences Microsomal triglyceride transfer protein lcsh:Microbiology low density lipoprotein cholesterol Eating Feces Immunology and Allergy hyperlipidemia Monascus purpureus Acetyl-CoA C-Acetyltransferase biology General Medicine Monascus Lipids Infectious Diseases Liver Apolipoprotein B-100 Apolipoprotein A1 lipids (amino acids peptides and proteins) Lovastatin Heterocyclic Compounds 3-Ring medicine.drug Microbiology (medical) medicine.medical_specialty Hypercholesterolemia Diet High-Fat Bile Acids and Salts 03 medical and health sciences ankaflavin Flavins 010608 biotechnology Internal medicine Immunology and Microbiology(all) medicine Animals Apolipoprotein A-I General Immunology and Microbiology Body Weight Cholesterol HDL Lipid metabolism Cholesterol LDL biology.organism_classification Rats 030104 developmental biology Endocrinology monascin Fermentation biology.protein Carrier Proteins |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 51, Iss 1, Pp 27-37 (2018) |
| ISSN: | 1684-1182 |
| Popis: | Background/purposes Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus NTU 568 were proven to show excellent hypolipidemic effects in our previous studies; however, the mechanism is still unclear. Methods This study used MS, AK, and monacolin K as test substances and performed tests on rats fed high-fat and high-cholesterol diet for 8 weeks. The lipid levels and the related protein levels of the rats were assessed to understand the effects of MS, AK, and monacolin K on lipid metabolism. Results MS and AK lowered low-density lipoprotein cholesterol (LDL-C) and preserved high-density lipoprotein cholesterol contents. MS and AK inhibited acetyl-coenzyme A acetyltransferase, microsomal triglyceride transfer protein, and apolipoprotein (apo) B-100 expression, thereby preventing LDL assembly. In addition, enhanced LDL-receptor expression increased the transport of LDL-C to the liver for metabolism. MS and AK also significantly increase apo A1 expression, which facilitates high-density lipoprotein cholesterol formation. Conclusion Monascus-fermented MS and AK can perform blood lipid regulation via the suppression of LDL-C assembly and stimulation of apo A1 expression in liver. |
| Databáze: | OpenAIRE |
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