The effects of low dietary levels of polyunsaturates on alcohol-induced liver disease in rhesus monkeys
| Autor: | N Salem, R J Pawlosky, B M Flynn |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Erythrocytes medicine.medical_treatment Alcohol Ascorbic Acid Biology Lipoproteins VLDL Dinoprost Antioxidants chemistry.chemical_compound Liver disease Dietary Fats Unsaturated Fibrosis Liver Cirrhosis Alcoholic Internal medicine medicine Animals Plant Oils Vitamin A Linolenate Olive Oil chemistry.chemical_classification Aldehydes F2-Isoprostanes Ethanol Hepatology Fatty Acids medicine.disease Macaca mulatta Endocrinology chemistry Liver Fatty Acids Unsaturated Lipid Peroxidation Polyunsaturated fatty acid |
| Zdroj: | Hepatology (Baltimore, Md.). 26(6) |
| ISSN: | 0270-9139 |
| Popis: | Rhesus monkeys that were maintained on a diet containing low, yet adequate, amounts of vitamins C and E and in which linoleate and linolenate represented 1.4% and 0.08% of the total caloric intake, respectively, developed liver fibrosis after consuming alcohol (mean, 2.6 g kg -1 d -1 ) over a period of 3 years. In the liver, several polyunsaturated fatty acids including 18:2n6, 20:4n6, and 22:6n3 decreased compared with dietary controls, and similar findings were also observed in plasma lipoproteins and erythrocytes. The amount of alcohol consumed correlated positively with plasma lipid peroxidation products, 4-hydroxynonenal (4-HNE) and 8-isoprostane F 2 α, and negatively with 20:4n6 and 22:6n3 levels. These findings imply that alcoholics who also have a marginal intake of essential fatty acids and antioxidants in their diets may be at an increased risk of developing liver disease. (Hepatology 1997 Dec;26(6):1386-92) |
| Databáze: | OpenAIRE |
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