Comparison of SPECT/CT, MRI and CT in diagnosis of skull base bone invasion in nasopharyngeal carcinoma

Autor: Guoqian Zhang, Wang Ruihao, Yong-bin Ge, Zhi-gang Ren, Wen-hai Fu, Shuxu Zhang, Peng-hui Han, Jian-sheng Li
Rok vydání: 2014
Předmět:
Adult
Male
medicine.medical_specialty
Treatment response
medicine.medical_treatment
Tumor target
Biomedical Engineering
Bone Neoplasms
Single-photon emission computed tomography
Sensitivity and Specificity
Biomaterials
Image Processing
Computer-Assisted
otorhinolaryngologic diseases
medicine
Humans
Neoplasm Invasiveness
Aged
Tomography
Emission-Computed
Single-Photon
Contouring
Nasopharyngeal Carcinoma
medicine.diagnostic_test
business.industry
Carcinoma
Skull
Reproducibility of Results
Nasopharyngeal Neoplasms
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Radiation therapy
medicine.anatomical_structure
Nasopharyngeal carcinoma
Radiographic Image Interpretation
Computer-Assisted
Female
Radiology
Tomography
X-Ray Computed
business
Nuclear medicine
Zdroj: Bio-Medical Materials and Engineering. 24:1117-1124
ISSN: 1878-3619
0959-2989
Popis: Early detection of skull base invasion in nasopharyngeal carcinoma (NPC) is crucial for correct staging, assessing treatment response and contouring the tumor target in radiotherapy planning, as well as improving the patient's prognosis. To compare the diagnostic efficacy of single photon emission computed tomography/computed tomography (SPECT/CT) imaging, magnetic resonance imaging (MRI) and computed tomography (CT) for the detection of skull base invasion in NPC. Sixty untreated patients with histologically proven NPC underwent SPECT/CT imaging, contrast-enhanced MRI and CT. Of the 60 patients, 30 had skull base invasion confirmed by the final results of contrast-enhanced MRI, CT and six-month follow-up imaging (MRI and CT). The diagnostic efficacy of the three imaging modalities in detecting skull base invasion was evaluated. The rates of positive findings of skull base invasion for SPECT/CT, MRI and CT were 53.3%, 48.3% and 33.3%, respectively. The sensitivity, specificity and accuracy were 93.3%, 86.7% and 90.0% for SPECT/CT fusion imaging, 96.7%, 100.0% and 98.3% for contrast-enhanced MRI, and 66.7%, 100.0% and 83.3% for contrast-enhanced CT. MRI showed the best performance for the diagnosis of skull base invasion in nasopharyngeal carcinoma, followed closely by SPECT/CT. SPECT/CT had poorer specificity than that of both MRI and CT, while CT had the lowest sensitivity.
Databáze: OpenAIRE
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