Comparison of SPECT/CT, MRI and CT in diagnosis of skull base bone invasion in nasopharyngeal carcinoma
Autor: | Guoqian Zhang, Wang Ruihao, Yong-bin Ge, Zhi-gang Ren, Wen-hai Fu, Shuxu Zhang, Peng-hui Han, Jian-sheng Li |
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Rok vydání: | 2014 |
Předmět: |
Adult
Male medicine.medical_specialty Treatment response medicine.medical_treatment Tumor target Biomedical Engineering Bone Neoplasms Single-photon emission computed tomography Sensitivity and Specificity Biomaterials Image Processing Computer-Assisted otorhinolaryngologic diseases medicine Humans Neoplasm Invasiveness Aged Tomography Emission-Computed Single-Photon Contouring Nasopharyngeal Carcinoma medicine.diagnostic_test business.industry Carcinoma Skull Reproducibility of Results Nasopharyngeal Neoplasms Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Radiation therapy medicine.anatomical_structure Nasopharyngeal carcinoma Radiographic Image Interpretation Computer-Assisted Female Radiology Tomography X-Ray Computed business Nuclear medicine |
Zdroj: | Bio-Medical Materials and Engineering. 24:1117-1124 |
ISSN: | 1878-3619 0959-2989 |
Popis: | Early detection of skull base invasion in nasopharyngeal carcinoma (NPC) is crucial for correct staging, assessing treatment response and contouring the tumor target in radiotherapy planning, as well as improving the patient's prognosis. To compare the diagnostic efficacy of single photon emission computed tomography/computed tomography (SPECT/CT) imaging, magnetic resonance imaging (MRI) and computed tomography (CT) for the detection of skull base invasion in NPC. Sixty untreated patients with histologically proven NPC underwent SPECT/CT imaging, contrast-enhanced MRI and CT. Of the 60 patients, 30 had skull base invasion confirmed by the final results of contrast-enhanced MRI, CT and six-month follow-up imaging (MRI and CT). The diagnostic efficacy of the three imaging modalities in detecting skull base invasion was evaluated. The rates of positive findings of skull base invasion for SPECT/CT, MRI and CT were 53.3%, 48.3% and 33.3%, respectively. The sensitivity, specificity and accuracy were 93.3%, 86.7% and 90.0% for SPECT/CT fusion imaging, 96.7%, 100.0% and 98.3% for contrast-enhanced MRI, and 66.7%, 100.0% and 83.3% for contrast-enhanced CT. MRI showed the best performance for the diagnosis of skull base invasion in nasopharyngeal carcinoma, followed closely by SPECT/CT. SPECT/CT had poorer specificity than that of both MRI and CT, while CT had the lowest sensitivity. |
Databáze: | OpenAIRE |
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